1. Mechanisms behind Functional Avidity Maturation in T Cells.
- Author
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Von Essen, Marina Rode, Kongsbak, Martin, and Geisler, Carsten
- Subjects
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T cells , *IMMUNE response , *ANTIBODY formation , *ANTIGENS , *B cells - Abstract
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional aviditymaturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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