1. PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant
- Author
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Wójtowicz, A., Lecompte, T.D., Bibert, S., Manuel, O., Rüeger, S., Berger, C., Boggian, K., Cusini, A., Garzoni, C., Hirsch, H., Khanna, N., Mueller, N.J., Meylan, P.R., Pascual, M., van Delden, C., Bochud, P.Y., University of Zurich, Bochud, Pierre-Yves, Swiss Transplant Cohort Study, Achermann, R., Aubert, JD., Baumann, P., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, PY., Boely, E., Bucher, H., Bühler, L., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Gasche, Y., Soccal, PG., Giostra, E., Golshayan, D., Good, D., Hadaya, K., Hess, C., Hillinger, S., Hirsch, HH., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Kuntzen, T., Laesser, B., Lehmann, R., Lovis, C., Manuel, O., Marti, HP., Martin, PY., Meylan, P., Mohacsi, P., Morard, I., Morel, P., Mueller, U., Mueller, NJ., Mueller-McKenna, H., Müller, T., Müllhaupt, B., Nadal, D., Nair, G., Pascual, M., Passweg, J., Ziegler, CP., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Seiler, C., Semmo, N., Stampf, S., Steiger, J., Toso, C., Tsinalis, D., Van Delden, C., Venetz, JP., Villard, J., Wick, M., Wilhelm, M., and Yerly, P.
- Subjects
10234 Clinic for Infectious Diseases ,ddc:616 ,10219 Clinic for Gastroenterology and Hepatology ,10036 Medical Clinic ,10209 Clinic for Cardiology ,C-Reactive Protein/genetics ,Female ,Fungi/isolation & purification ,Humans ,Immunocompromised Host ,Male ,Mycoses/genetics ,Mycoses/immunology ,Organ Transplantation/adverse effects ,Polymorphism, Genetic ,Prospective Studies ,Serum Amyloid P-Component/genetics ,610 Medicine & health ,2725 Infectious Diseases ,2726 Microbiology (medical) - Abstract
Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.
- Published
- 2015
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