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A study conducted by researchers at Emory University explores the potential use of the neutrophil-to-lymphocyte ratio (NLR) as a biomarker for predicting outcomes in patients with spinal cord injury (SCI). The study involved a thorough review of relevant articles and identified three clinical studies that met the inclusion criteria. The researchers found that the NLR could serve as an independent predictor of both mortality and recovery outcomes in patients with SCI, but further data is needed to reach a conclusive decision. The study highlights the potential value of the NLR as a cost-effective and readily available marker for predicting outcomes in SCI patients. [Extracted from the article]

A new report from Universitas Sebelas Maret in Surakarta, Indonesia, discusses the role of the platelet-to-lymphocyte ratio (PLR) as a prognostic predictive marker in adults with traumatic brain injury (TBI). The study conducted a systematic review of relevant studies and found that a high level of admission PLR may independently predict an increasing mortality risk in 30 days and adverse outcomes in 6 months following TBI. However, one study suggests that PLR may have limited value compared to other hematological parameters. The research concludes that PLR can be utilized as a simple, low-cost, and routine hematological examination in rural practice. [Extracted from the article]

A clinical trial, NCT06420284, has been launched to analyze the immunological response profiles at different clinical stages of medication-related osteonecrosis of the jaw (MRONJ). The study aims to understand how these responses affect the pathogenesis, staging, and treatment of MRONJ. The trial will comprehensively assess cytokine levels, inflammation markers, and other immunological parameters to provide insights into stage-specific immunological variables that could inform the diagnosis and treatment of MRONJ. The study is currently recruiting participants and is expected to be completed by May 2025. [Extracted from the article]