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A study conducted at Massachusetts General Hospital in Boston, Massachusetts, explored the use of tranexamic acid (TXA) in percutaneous nephrolithotomy (PCNL), a procedure for treating large renal stones. The study analyzed existing evidence through a Bayesian network meta-analysis and found that TXA, whether administered systemically or as part of irrigation fluid, effectively reduced bleeding, postoperative complications, and the risk of transfusion compared to a placebo. The researchers suggested that further studies comparing systemic TXA to TXA in irrigation fluid would be beneficial in determining the optimal route of delivery. This research has been peer-reviewed and published in the Canadian Urological Association Journal. [Extracted from the article]

The article focuses on the effectiveness and safety of combining East Asian herbal medicine (EAHM) with narrowband ultraviolet B (NB-UVB) therapy for treating psoriasis. Topics include the comparative analysis of this combination therapy versus NB-UVB alone, statistical outcomes from randomized controlled trials, and the need for further high-quality research to validate these findings.

A recent study conducted by researchers at Western University in London, Canada, aimed to evaluate the effectiveness of remote rehabilitation interventions for individuals with chronic musculoskeletal pain and depression. The study analyzed 58 randomized controlled trials involving 10,278 participants and found that interactive voice response cognitive behavioral therapy (CBT), in-person CBT, and mobile app CBT plus exercise were superior to waitlist control in reducing pain. Internet-delivered CBT and telecare were also found to be superior to waitlist control in improving depression outcomes. The study concluded that these remote rehabilitation interventions show promise in managing chronic musculoskeletal pain and depression. [Extracted from the article]

A study conducted by Xinjiang Medical University in China evaluated the long-term prognosis of patients with functional mitral regurgitation (FMR) who underwent different treatments, including percutaneous intervention, surgical intervention, or optimal medical therapy. The study found that there was no significant difference in prognosis for all-cause mortality among the three treatment modalities. However, surgery was found to be superior to transcatheter intervention and optimal drug therapy in terms of improving the degree of regurgitation and left ventricular ejection fraction (LVEF). The study concluded that surgery showed better outcomes in these specific areas. [Extracted from the article]

A study conducted at Zaozhuang Municipal Hospital examined treatment options for non-small cell lung cancer (NSCLC) after the failure of immune checkpoint inhibitors (ICIs). The researchers conducted a network meta-analysis (NMA) using data from Phase II and III randomized controlled trials (RCTs). The results showed that the combination of tyrosine kinase inhibitor (TKI) and chemotherapy (TKI + Chemo) was associated with longer progression-free survival (PFS) and higher objective response rate (ORR), while the combination of ICI and TKI (ICI + TKI) had the longest overall survival (OS). In terms of safety, the combination of ICI and anti-angiogenic monoclonal antibody (ICI + Antiangio-Ab) had the highest safety rating. [Extracted from the article]

A study conducted in West Bengal, India compared the efficacy of two drugs, saroglitazar and pioglitazone, in treating non-alcoholic fatty liver disease (NAFLD). The study analyzed data from 12 randomized prospective studies involving a total of 930 NAFLD patients. The results showed that both saroglitazar and pioglitazone had comparable effects in improving inflammatory markers and biopsy parameters in NAFLD patients. The study concluded that the efficacy of saroglitazar in treating NAFLD is similar to that of pioglitazone. [Extracted from the article]

A study conducted by researchers at Radboud University Medical Center explored depression interventions in nursing home residents. The researchers conducted a Bayesian network meta-analysis of randomized controlled trials to examine the effectiveness of different interventions in reducing depressive symptoms. They found that cognitive interventions, such as cognitive behavioral therapy and goal-oriented therapy, showed the strongest effects compared to care as usual. The severity of depressive symptoms also moderated the effect of interventions. The study highlights the need for continued research and the consideration of residents' factors when choosing interventions for depression in nursing home residents. [Extracted from the article]

A study conducted by the Monterrey Institute of Technology and Higher Education in Mexico analyzed the effectiveness of low-intensity shockwave therapy for erectile dysfunction. The study included 1,272 patients from 18 studies and found that sessions featuring 1,500 pulses and an energy flux density of 0.15 mJ/mm(2) were the most effective. The research suggests that low-intensity shockwave therapy is an effective intervention for erectile dysfunction. [Extracted from the article]

A new study from the China Academy of Chinese Medical Sciences explores the effects of different oral anticoagulants on cognitive decline in patients with atrial fibrillation (AF). The researchers conducted a Bayesian network meta-analysis and found that vitamin K antagonists (VKAs) may be the most effective intervention for reducing the risk of cognitive decline in AF patients. However, the study acknowledges its limitations and calls for more high-quality randomized controlled trials to provide further evidence. This research provides valuable insights for healthcare professionals and patients seeking treatment options for AF. [Extracted from the article]

Researchers from Peking University School and Hospital of Stomatology in Beijing, China, conducted a study to determine the effectiveness of botulinum toxin A (BTA) injections in relieving pain caused by bruxism. They analyzed 11 controlled clinical trials involving 365 bruxism patients and found that BTA injections significantly reduced bruxism-related pain, with the greatest relief occurring in the first 6 months after treatment. The study also showed that BTA was more effective than oral splinting or saline injections. However, the researchers recommend further long-term randomized controlled trials to compare BTA with other management or drugs. [Extracted from the article]

A recent meta-analysis conducted by researchers at the National University of Singapore aimed to evaluate the efficacy of different treatment modalities for apathy in Parkinson's disease (PD). The study included 19 randomized controlled trials involving 2,372 patients and found that pharmacotherapy was the most effective treatment option for reducing apathy scores in PD. Specifically, dopamine agonists and alternative medications were found to have similar efficacy. However, further research is needed to determine the optimal management strategy for apathy in PD. [Extracted from the article]

A new report from the Department of Innovative Technologies in Medicine and Dentistry in Chieti, Italy, presents findings on the mechanical strength and biological response of dental implant prosthetic joints. The study conducted a systematic review and meta-analysis of randomized clinical trials to evaluate different types of internal/external bi-phasic implants. The results showed that the cone morse (CM) joint had a more consistent control of marginal bone loss and a lower rate of prosthetic complications compared to other joint types. However, the researchers noted that there were limitations to the study and differences in dental implant properties. [Extracted from the article]

A study conducted at Western University examined the efficacy of advanced therapies for patients with moderately to severely active ulcerative colitis who were naive to advanced therapy. The study used a Bayesian network meta-analysis to compare the effectiveness of different treatments. The results showed that etrasimod, an oral medication, had similar efficacy to most other treatments in inducing and maintaining clinical remission and clinical response. The study highlights the importance of considering trial design and risk-benefit profiles when interpreting the results of network meta-analyses. [Extracted from the article]

A research study conducted by Guangzhou University of Chinese Medicine in Guangdong, China, aims to evaluate the effectiveness of various acupuncture techniques in treating postmenopausal osteoporosis. The study will analyze randomized controlled trials of different acupuncture-related therapies from 2002 to 2022. The primary outcome indicators include clinical efficacy rate, bone mineral density, and Visual Analogue Scale score, while adverse reactions will be considered as a secondary outcome. The results of this network meta-analysis will be published in a recognized journal. [Extracted from the article]

A recent study conducted by researchers at the University of Alabama proposes the use of Bayesian network models to assess the probability of posttraumatic stress disorder (PTSD) in veterans seeking medical care at U.S. Department of Veteran Affairs (VA) facilities. The study aims to improve the current practice of using a five-question test called PC-PTSD-5 by incorporating demographic information, military service history, and medical history. The researchers identified several features that help compute the probability of PTSD, including the PC-PTSD-5 test, service-connected flag, combat flag, agent orange flag, military sexual trauma flag, traumatic brain injury, and age. The study has been peer-reviewed and provides valuable insights for mental healthcare workers in making treatment decisions for veterans. [Extracted from the article]

Researchers at University Hospital Essen in Germany conducted a study to evaluate the effectiveness of different radiotherapy strategies in patients with newly diagnosed glioblastoma, a type of brain cancer. The study included a comprehensive literature review of randomized controlled trials and comparative nonrandomized studies, focusing on overall survival and progression-free survival. The findings indicated that proton therapy showed improved overall survival and progression-free survival compared to other radiotherapy strategies. The researchers suggest that proton therapy may be a standard treatment option for selected patients with glioblastoma. [Extracted from the article]

A recent study conducted at Massachusetts General Hospital in Boston, Massachusetts, examined the pharmacological management of symptoms related to ureteral stents. Ureteral stents are commonly used to treat ureteral obstruction, but they can cause bothersome symptoms and discomfort. The study utilized Bayesian network meta-analysis to analyze the available evidence on the effectiveness of different medication regimens for managing these symptoms. The results showed that the most effective drug therapy varied depending on the specific symptom domain, such as urinary symptoms, pain, sexual performance, general health, and work performance. The researchers concluded that further trials directly comparing these drugs would strengthen future analyses. [Extracted from the article]

Keywords: St. Louis; State:Missouri; United States; North and Central America; Bayesian Networks; Health and Medicine; Opioids; Pharmacology; Placebos; Pruritus; Risk and Prevention; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Therapy EN St. Louis State:Missouri United States North and Central America Bayesian Networks Health and Medicine Opioids Pharmacology Placebos Pruritus Risk and Prevention Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Therapy 596 596 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Research findings on Opioids are discussed in a new report. We judged five interventions to be "definitely superior" to placebo: propofol, opioid agonist-antagonists (neuraxial), opioid antagonists, opioid agonist-antagonists (systemic), and serotonin antagonists. [Extracted from the article]

Keywords for this news article include: Guangzhou, People's Republic of China, Asia, Chemicals and Chemistry, Analgesic Agents, Antiinflammatory Agents, Bayesian Networks, Biphenyl Compounds, Carboxylic Acids, Clinical Research, Clinical Trials and Studies, Flurbiprofen Therapy, Health and Medicine, Hydrocarbons, Organic Chemicals, Propionic Acids, Sun Yat-sen University. Keywords: Guangzhou; People's Republic of China; Asia; Chemicals and Chemistry; Analgesic Agents; Antiinflammatory Agents; Bayesian Networks; Biphenyl Compounds; Carboxylic Acids; Clinical Research; Clinical Trials and Studies; Flurbiprofen Therapy; Health and Medicine; Hydrocarbons; Organic Chemicals; Propionic Acids EN Guangzhou People's Republic of China Asia Chemicals and Chemistry Analgesic Agents Antiinflammatory Agents Bayesian Networks Biphenyl Compounds Carboxylic Acids Clinical Research Clinical Trials and Studies Flurbiprofen Therapy Health and Medicine Hydrocarbons Organic Chemicals Propionic Acids 900 900 1 08/28/23 20230829 NES 230829 2023 AUG 28 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Chemicals and Chemistry have been published. Guangzhou, People's Republic of China, Asia, Chemicals and Chemistry, Analgesic Agents, Antiinflammatory Agents, Bayesian Networks, Carboxylic Acids, Clinical Research, Clinical Trials and Studies, Flurbiprofen Therapy, Health and Medicine, Hydrocarbons, Organic Chemicals, Propionic Acids, Biphenyl Compounds. [Extracted from the article]

Keywords: Tianjin; People's Republic of China; Asia; Bayesian Networks; Chemotherapy; Clinical Research; Clinical Trials and Studies; Drugs and Therapies; Health and Medicine; Peripheral Neuropathy EN Tianjin People's Republic of China Asia Bayesian Networks Chemotherapy Clinical Research Clinical Trials and Studies Drugs and Therapies Health and Medicine Peripheral Neuropathy 1664 1664 1 08/28/23 20230829 NES 230829 2023 AUG 28 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on Peripheral Neuropathy are presented in a new report. According to news reporting originating from Tianjin, People's Republic of China, by NewsRx correspondents, research stated, "Chemotherapy-induced peripheral neuropathy (CIPN) reduces the quality-of-life, affects recovery, and increases the risk of chemotherapeutic failure. [Extracted from the article]

Autoimmune Diseases and Conditions, Bayesian Networks, Connective Tissue Diseases and Conditions, Health and Medicine, Kidney Diseases and Conditions, Lupus, Lupus Nephritis, Systemic Lupus Erythematosus Keywords: Autoimmune Diseases and Conditions; Bayesian Networks; Connective Tissue Diseases and Conditions; Health and Medicine; Kidney Diseases and Conditions; Lupus; Lupus Nephritis; Systemic Lupus Erythematosus EN Autoimmune Diseases and Conditions Bayesian Networks Connective Tissue Diseases and Conditions Health and Medicine Kidney Diseases and Conditions Lupus Lupus Nephritis Systemic Lupus Erythematosus 1381 1381 1 08/21/23 20230821 NES 230821 2023 AUG 21 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on lupus nephritis. [Extracted from the article]

Keywords for this news article include: New Delhi, India, Asia, Bayesian Networks, Blood Diseases and Conditions, Bloodstream Infection, Clinical Research, Clinical Trials and Studies, Health and Medicine, Risk and Prevention, Sepsis, Septicemia, All India Institute of Medical Sciences (AIIMS). Keywords: New Delhi; India; Asia; Bayesian Networks; Blood Diseases and Conditions; Bloodstream Infection; Clinical Research; Clinical Trials and Studies; Health and Medicine; Risk and Prevention; Sepsis; Septicemia EN New Delhi India Asia Bayesian Networks Blood Diseases and Conditions Bloodstream Infection Clinical Research Clinical Trials and Studies Health and Medicine Risk and Prevention Sepsis Septicemia 162 162 1 08/21/23 20230821 NES 230821 2023 AUG 24 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Research findings on Blood Diseases and Conditions - Sepsis are discussed in a new report. [Extracted from the article]

For more information on this research see: Bayesian Network Meta-analysis of Randomized Controlled Trials On the Efficacy of Antiarrhythmics In the Pharmacological Cardioversion of Paroxysmal Atrial Fibrillation. Keywords: Udine; Italy; Europe; Antiarrhythmic Agents; Atrial Fibrillation; Bayesian Networks; Cardiac Arrhythmias; Clinical Research; Clinical Trials and Studies; Drugs and Therapies; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Pharmacology; Therapy EN Udine Italy Europe Antiarrhythmic Agents Atrial Fibrillation Bayesian Networks Cardiac Arrhythmias Clinical Research Clinical Trials and Studies Drugs and Therapies Health and Medicine Heart Disease Heart Disorders and Diseases Pharmacology Therapy 790 790 1 07/17/23 20230717 NES 230717 2023 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Heart Disorders and Diseases - Atrial Fibrillation. [Extracted from the article]

Keywords: Bayesian Networks; Health and Medicine; Oncology; Pharmacology; Therapy EN Bayesian Networks Health and Medicine Oncology Pharmacology Therapy 1515 1515 1 07/17/23 20230717 NES 230717 2023 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Research findings on oncology are discussed in a new report. For more information on this research see: Efficacy of Different Pharmacological Interventions for Cervical High-risk HPV Infection: Bayesian Network Meta-analysis. [Extracted from the article]

Keywords: Sichuan; People's Republic of China; Asia; Bayesian Networks; Bone Research; Clinical Research; Clinical Trials and Studies; Dental Diseases and Conditions; Dentistry; Health and Medicine; Malocclusion; Orthopedics; Stomatognathic Diseases and Conditions; Tooth Diseases and Conditions EN Sichuan People's Republic of China Asia Bayesian Networks Bone Research Clinical Research Clinical Trials and Studies Dental Diseases and Conditions Dentistry Health and Medicine Malocclusion Orthopedics Stomatognathic Diseases and Conditions Tooth Diseases and Conditions 946 946 1 06/19/23 20230619 NES 230619 2023 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Dental Diseases and Conditions - Malocclusion. Sichuan, People's Republic of China, Asia, Bayesian Networks, Bone Research, Clinical Research, Clinical Trials and Studies, Dental Diseases and Conditions, Dentistry, Health and Medicine, Malocclusion, Orthopedics, Stomatognathic Diseases and Conditions, Tooth Diseases and Conditions. [Extracted from the article]

Keywords: Xinjiang; People's Republic of China; Asia; Mathematics; Bayesian Networks EN Xinjiang People's Republic of China Asia Mathematics Bayesian Networks 1154 1154 1 06/19/23 20230619 NES 230619 2023 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Mathematics have been published. According to news reporting out of Xinjiang, People's Republic of China, by NewsRx editors, research stated, "Silver formulation has been used for external use of burn wounds for several decades, mainly including silver sulfadiazine (SSD), nanosilver dressing (NSD), and silver ion dressing (SID). [Extracted from the article]

Keywords: Activities of Daily Living; Bayesian Networks; Cerebrovascular Diseases and Conditions; Clinical Research; Clinical Trials and Studies; Drugs and Therapies; Health and Medicine; Rehabilitation; Stroke EN Activities of Daily Living Bayesian Networks Cerebrovascular Diseases and Conditions Clinical Research Clinical Trials and Studies Drugs and Therapies Health and Medicine Rehabilitation Stroke 836 836 1 06/12/23 20230612 NES 230612 2023 JUN 12 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in stroke. According to the news editors, the research concluded: "This Bayesian network meta-analysis results showed that the combination of ginkgo biloba-related agents and WM was more effective for AIS patients than WM alone. [Extracted from the article]

Anxiolytics Sedatives and Hypnotics, Bayesian Networks, Drugs and Therapies, Pharmaceuticals, Suvorexant Therapy Keywords: Anxiolytics Sedatives and Hypnotics; Bayesian Networks; Drugs and Therapies; Pharmaceuticals; Suvorexant Therapy EN Anxiolytics Sedatives and Hypnotics Bayesian Networks Drugs and Therapies Pharmaceuticals Suvorexant Therapy 1209 1209 1 05/29/23 20230529 NES 230529 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on anxiolytics sedatives and hypnotics are presented in a new report. [Extracted from the article]

Keywords: Bayesian Networks; Data Acquisition; Emerging Technologies; Information Technology; Machine Learning; Naive Bayes Classifier EN Bayesian Networks Data Acquisition Emerging Technologies Information Technology Machine Learning Naive Bayes Classifier 1125 1125 1 05/22/23 20230523 NES 230523 2023 MAY 22 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on data acquisition. Bayesian Networks, Emerging Technologies, Information Technology, Machine Learning, Naive Bayes Classifier, Data Acquisition. [Extracted from the article]

Keywords for this news article include: Fudan University, Shanghai, People's Republic of China, Asia, Antibiotics, Antineoplastics, Pharmaceuticals, Oncology, Lung Cancer, Chemotherapy, Lung Neoplasms, Amrubicin Therapy, Bayesian Networks, Enzyme Inhibitors, Topotecan Therapy, Drugs and Therapies, Health and Medicine, Lung Diseases and Conditions. Keywords: Amrubicin Therapy; Antibiotics; Antineoplastics; Bayesian Networks; Cancer; Chemotherapy; Drugs and Therapies; Enzyme Inhibitors; Health and Medicine; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Oncology; Pharmaceuticals; Topotecan Therapy EN Amrubicin Therapy Antibiotics Antineoplastics Bayesian Networks Cancer Chemotherapy Drugs and Therapies Enzyme Inhibitors Health and Medicine Lung Cancer Lung Diseases and Conditions Lung Neoplasms Oncology Pharmaceuticals Topotecan Therapy 194 194 1 04/03/23 20230403 NES 230403 2023 APR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on lung cancer have been published. [Extracted from the article]

Compared with dopamine, the mean difference (95% credible interval) of ScO2 reduction was: ephedrine -3.19 (-15.74, 8.82), norepinephrine -4.44 (-18.23, 9.63) and phenylephrine -6.93 (-18.31, 4.47). Keywords: Stanford; State:California; United States; North and Central America; Adrenergic alpha-Agonist; Amino Alcohols; Anorectal Preparations; Bayesian Networks; Biogenic Amines; Cardiotonic; Cardiovascular Agents; Cardiovascular Diseases and Conditions; Catecholamines; Chalcogens; Clinical Research; Clinical Trials and Studies; Dopamine; Dopamine Hydrochloride; Drugs and Therapies; Ephedrine; Epinephrine; Ethanolamines; Health and Medicine; Hypotension; Mydriatics; Nasal Decongestants; Norepinephrine; Norepinephrine Therapy; Ophthalmic Preparations; Organic Chemicals; Pharmaceuticals; Phenethylamines; Phenylephrine; Phenylephrine Therapy; Propanolamines; Sympathomimetic; Vasoconstrictor Agents; Vasopressors EN Stanford State:California United States North and Central America Adrenergic alpha-Agonist Amino Alcohols Anorectal Preparations Bayesian Networks Biogenic Amines Cardiotonic Cardiovascular Agents Cardiovascular Diseases and Conditions Catecholamines Chalcogens Clinical Research Clinical Trials and Studies Dopamine Dopamine Hydrochloride Drugs and Therapies Ephedrine Epinephrine Ethanolamines Health and Medicine Hypotension Mydriatics Nasal Decongestants Norepinephrine Norepinephrine Therapy Ophthalmic Preparations Organic Chemicals Pharmaceuticals Phenethylamines Phenylephrine Phenylephrine Therapy Propanolamines Sympathomimetic Vasoconstrictor Agents Vasopressors 2023 FEB 13 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Cardiovascular Diseases and Conditions - Hypotension. [Extracted from the article]

For more information on this research see: Comparison ofthe Efficacy of Acupuncture-related Therapies forPost-stroke Motor Aphasia: a Bayesian NetworkMeta-analysis. Speech Language and Learning Diseases andConditions - Aphasia Investigators discuss new findings in Speech Language andLearning Diseases and Conditions - AphAsia. [Extracted from the article]