1. Influence of polymer coating on release of l-dopa from core-shell Fe@Au nanoparticle systems.
- Author
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Bandyopadhyay, Sulalit, Alvi, Muhammad, Sharma, Anuvansh, Zhu, Kaizheng, Kjøniksen, Anna-Lena, Nyström, Bo, and Glomm, Wilhelm
- Subjects
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DOPA , *NANOPARTICLES , *LIGHT scattering , *ULTRAVIOLET spectroscopy , *MICROGELS - Abstract
We report on the effect of different stimuli-responsive polymer shells on Fe@Au core-shell nanoparticles (NPs) with respect to thermoresponse as well as loading and release characteristics. The hybrid NP systems were investigated using a wide array of characterization techniques including dynamic light scattering, electrophoretic mobility, UV-visible spectroscopy, and scanning transmission electron microscopy. Three different polymeric shells were selected for loading and release of l-dopa: thiolated polyethylene glycol (PEG), poly( N-isopropylacrylamide- co-acrylic acid) (PNIPAAM_AAc) microgel crosslinked with N, N′-methylenebis(acrylamide) (BIS), and finally concomitant PEG and PNIPAAM_AAc microgel (Fe@Au_PEG_Microgel). All three shells were found to exhibit high loading (∼10%) and encapsulation efficiencies up to 100 μg l-dopa/mg. Although the loading efficiencies are comparable for the three systems, Fe@Au_PEG_Microgel has the highest release (87%) at elevated temperature and acidic conditions. The attenuated release from the PEG-based systems can be attributed to stronger dipole-dipole interactions between the carboxyl group of PEG and the amino group of l-dopa. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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