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A conference paper on the role of apoptosis inhibitor expressed by macrophages (AIM) in Corynebacterium-induced granuloma formation in mice is presented. Results reveal the poor repopulation of natural killer T (NKT) cells in middle and late stages of granuloma formation in AIM-/-mice. Apoptosis of NKT cells and T cells was more prominent in AIM-/- mice. These findings indicate that AIM regulates NKT and T cell apoptosis and recruitment and plays a vital role in granuloma formation.

A conference report on the immunomodulatory role of kupffer cell (KC)in liver allografts is presented. It zeroes in on Fas ligand expression and their role in allo-reactive T cell apoptosis in chronic accepted and acutely rejected hepatic allografts. Results reveal that KC induced apoptosis and lysis of allo-reactive T cells, and this lysis effect was inhibited by anti-FasL antibody.