1. Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies.
- Author
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Pinson, Anneline, Franssen, Delphine, Gérard, Arlette, Parent, Anne-Simone, and Bourguignon, Jean-Pierre
- Subjects
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NEUROENDOCRINE system , *ENDOCRINE disruptors , *BISPHENOL A , *BIOCHEMICAL mechanism of action , *CENTRAL nervous system - Abstract
Endocrine disruption is commonly thought to be restricted to a direct endocrine mode of action i.e. the perturbation of the activation of a given type of hormonal receptor by its natural ligand. Consistent with the WHO definition of an endocrine disrupter, a key issue is the “altered function(s) of the endocrine system”. Such altered functions can result from different chemical interactions, beyond agonistic or antagonistic effect at a given receptor. Based on neuroendocrine disruption by polychlorinated biphenyls and bisphenol A, this paper proposes different mechanistic paradigms that can result in adverse health effects. They are a consequence of altered endocrine function(s) secondary to chemical interaction with different steps in the physiological regulatory processes, thus accounting for a possibly indirect endocrine mode of action. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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