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1. Methods for measuring DNA adducts and abasic sites II: methods for measurement of DNA adducts.

Author

Swenberg JA, Ham AJ, Koc H, La DK, Morinello EJ, Pachkowski BF, Ranasinghe A, and Upton PB

Subjects
Cell Line, Chromatography, Affinity methods, Chromatography, High Pressure Liquid methods, Electrochemical Techniques, Gas Chromatography-Mass Spectrometry, Humans, Spectrometry, Mass, Electrospray Ionization, Tandem Mass Spectrometry, DNA chemistry, DNA Adducts analysis
Abstract

This unit contains protocols for analyzing DNA adducts separated from the DNA backbone. HPLC is used to quantify total guanine or ribo- or deoxynucleotides as well as methods for analyzing specific adducts. These methods include HPLC with electrochemical detection, immunoaffininty chromatography to enrich for specific adducts, and gas and liquid chromatography in combination with HPLC and mass spectrometry.

Published
2002
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