1. Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents
- Author
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Carlos F. G. C. Geraldes, S. W. Annie Bligh, Miao Jin, Gareth R. Williams, and Dominic E.M. Spillane
- Subjects
Gadolinium DTPA ,Ion exchange ,Chemistry ,Gadolinium ,Intercalation (chemistry) ,chemistry.chemical_element ,Infrared spectroscopy ,Contrast Media ,Magnetic Resonance Imaging ,Inorganic Chemistry ,Crystallography ,Nuclear magnetic resonance ,Organophosphorus Compounds ,Coordination Complexes ,lipids (amino acids, peptides, and proteins) ,Salts ,Emission spectrum - Abstract
The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd(3+) diethylenetriaminepentaacetate and Gd(3+) diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5-18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd(3+) complexes in the intercalation compounds. The proton relaxivities of the Gd(3+) complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.
- Published
- 2015