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Introduction: Follicular lymphoma is the second most common type of lymphoma, originating from B cells. It presents with long-term asymptomatic lymphadenopathy and involvement of other organs is rare. Case report: A 92-year-old woman reported to the Department of Dermatology with skin lesions persisting for 6 months. She had previously been treated for erysipelas and "a tumour of unknown origin". A biopsy had been taken in the past, but the microscopic image was non-specific. The patient was thus treated with antibiotics, without further diagnostics. At the department, numerous firm pink-red nodules on the right lower leg were observed. Another biopsy was taken - the microscopic image and immunohistochemical profile were consistent with secondary skin involvement by follicular lymphoma. The patient was referred to the Lymphatic Tumour Centre, but refused further treatment and soon died. Conclusions: Secondary skin involvement by follicular lymphoma is very rare and diagnosis may be delayed. If the histopathological result does not match the clinical picture of the skin lesions, a repeat biopsy is indicated. [ABSTRACT FROM AUTHOR]

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. Acrodermatitis continua Hallopeau (ACH) is a rare form of psoriasis. Sterile pustules are usually located in the area of the fingertips and nails at the site of injury or infection. Nail lesions are always present. Case report. A 65-year-old man was admitted to the Department of Dermatology for diagnostics and treatment of lesions of the skin and fingernails that developed as a consequence of an injury. Initially, he was treated on an outpatient basis with topical glucocorticoids, without improvement. On admission, numerous pustules, maceration of the epidermis, severe hyperkeratosis of the skin in distal parts of fingers and soles, and swollen, red nail folds with dystrophy of many finger and toe nail plates were observed. Acitretin was introduced. An improvement in the condition of the skin was observed during the hospitalisation. An outpatient follow-up was recommended, during which further improvement was noted. Conclusions. Acrodermatitis continua Hallopeau is a chronic and progressive dermatosis that can lead to irreversible complications. The nail apparatus becomes affected early. Untreated acrodermatitis continua Hallopeau may lead to onychodystrophy or anonychia, and even to osteolysis of distal phalanges. So far, no specific guidelines for the treatment of acrodermatitis continua Hallopeau have been developed. [ABSTRACT FROM AUTHOR]

Psoriasis is a chronic, inflammatory, autoimmune skin disease affecting 2-4% of general population. It is an important social issue, because of its confirmed associations with metabolic syndrome. Individals with psoriasis are at an increased risk of developing cardiovascular disorders and diabetes mellitus. Psoriasis and its comorbidities have multiple common pathogenic pathways including the chronic inflammatory process, immunological abnormalities, genetic links and different bioactive proteins secreted by the adipose tissue. Considering the above associations, it is advisable to perform screening tests in patients with psoriasis to detect metabolic disorders as they not only increase mortality in these individuals, but also decrease their life quality significantly. An essential issue is also the education and the improvement of doctor-patient relationship, as well as early introducing of preventive measures. [ABSTRACT FROM AUTHOR]

Psoriasis is a chronic inflammatory skin disease affecting 2-4% of general population. Skin lesions may be accompanied by pruritus or pain, what may cause difficulties in daily functioning, and also disturb sleep. Many patients suffer from depression, which is often accompanied by sleep disorders, usually insomnia. Psoriasis is also strongly associated with metabolic syndrome and obesity, but also with obstructive sleep apnea syndrome. Research also shows that patients with psoriasis more frequently suffer from restless leg syndrome. Sleep disorders lead to significant deterioration of patients' quality of life, which is already decreased by the disease itself. Therefore, it is advisable to screen patients with psoriasis for sleep disorders, and introduce adequate treatment early during the course of the disease. [ABSTRACT FROM AUTHOR]

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Lupus tumidus is a rare type of chronic cutaneous lupus erythematosus characterized by recurring non-scarring, erythematous- -oedematous skin lesions, located on sun-exposed areas. Objective: To present two cases of patients with lupus tumidus. Case reports: 1. A 54-year-old woman was admitted to the Department of Dermatology due to erythematous-oedematous lesions on dorsal parts of hands, face and thighs, self-resolving. Broad evaluation for connective tissue disorders revealed no relevant abnormalities. Finally, lupus tumidus was diagnosed and hydroxychloroquine was introduced. During the therapy a breast cancer was diagnosed. 2. A 45-year-old woman presented to the Department in order to treat erythematousoedematous lesions located on the face, shoulders and upper torso that appeared 3 months earlier. The histopathological examination revealed lupus tumidus. Conclusions: Lupus erythematosus tumidus diagnosis may pose diagnostic difficulties. Among the types of lupus erythematosus, it is distinguished by regression without scarring, significant ultraviolet hypersensitivity and rapid clinical improvement after antimalarial drugs. [ABSTRACT FROM AUTHOR]

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. Folliculotropic mycosis fungoides is one of the mycosis fungoides variants with neoplastic T-helper lymphocytes infiltrating hair follicles. It often affects head and neck with a variety of lesions. Objective. To present a patient with folliculotropic mycosis fungoides and coexisting pancreatic neuroendocrine tumour. Case report. A 63-year-old male with a 15-year history of erythematous-papular exfoliating lesions with pruritus has been treated in ambulatory care. After 10 years he was referred to the hospital. Lesional biopsy was non-specific at that time. Five years later folliculotropic mycosis fungoides was diagnosed on the basis of clinical and histopathological features. The patient underwent Re-PUVA therapy with no improvement, and then methotrexate was introduced. At that time the diagnosis of coexisting pancreatic neuroendocrine tumour was made. Conclusions. Folliculotropic mycosis fungoides is a rare type of cutaneous T-cell lymphoma with a 5-year survival rate reaching 80%. The presented case highlights the possibility of atypical clinical features of the diseases and coexistence of other neoplastic comorbidities. [ABSTRACT FROM AUTHOR]

Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis. [ABSTRACT FROM AUTHOR]

Psoriasis is a chronic skin disease characterized by systemic inflammation associated with an increased risk of metabolic and cardiovascular complications. A special role in maintaining systemic inflammation is attributed to obesity. Adipose tissue is an active endocrine organ which, through adipokine secretion, is involved in the regulation of many systemic metabolic pathways. Obesity increases the risk of developing type 2 diabetes mellitus, atherosclerosis, cardiovascular diseases and hypertension. The paper presents the characteristics of two relatively recently discovered and little known adipokines: omentin and vaspin. They are considered to have beneficial effects preventing the development of metabolic disorders associated with obesity. In addition, attention was given to their possible involvement in the pathogenesis of psoriasis and potential use as markers of disease severity and the risk of developing metabolic complications. [ABSTRACT FROM AUTHOR]

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Apoptosis is a physiological mechanism of programmed cell death, in contrast to necrosis, without eliciting an inflammatory response. It plays the key role in the functioning of different tissues and organs. The balance between proliferation and apoptosis of keratinocytes is important for epidermal maintenance of homeostasis. Dysfunctional apoptosis plays an important role in the development of several skin disorders. Diseases with an increase of apoptosis are usually acute, while those with inhibited apoptosis tend to be chronic. Psoriasis is an immune-mediated chronic inflammatory skin disease. It is characterized by keratinocyte hyperproliferation and abnormal differentiation. Psoriatic keratinocytes are resistant to apoptosis and this phenomenon can be the key event in psoriatic hyperplasia. Apoptosis disturbances can also affect immune cells involved in the pathogenesis of psoriasis. In this review, we describe the basic concept of apoptosis and its relevance in psoriatic pathogenesis. [ABSTRACT FROM AUTHOR]

Psoriasis is a systemic disease in which chronic inflammation predisposes to the development of cardiovascular and metabolic disorders. This relationship is determined by the concept of psoriatic march. We present the characteristics of selected inflammatory factors - paraoxonase 1, galectin 3 and pentraxin 3 - involved in inflammatory processes, in the development of insulin resistance and cardiovascular diseases. Attention is drawn to their potential role in the pathogenesis of psoriasis and the possibility of their use as markers of early development of metabolic disorders. Early diagnosis and prevention of the development of metabolic complications in patients with psoriasis can help to extend and improve the comfort of their living. [ABSTRACT FROM AUTHOR]

Introduction. Autoimmune polyglandular syndrome type 1 (APS-1) is a type of polyendocrinopathy, inherited in an autosomal recessive manner. Beside the classic triad of symptoms (candidiasis of the skin and mucous membranes, hypoparathyroidism and Addison's disease), other skin and systemic diseases may be present. Objective. To present a patient with history of APS-1, in whom in addition to the classic triad of symptoms vitiligo, alopecia, and dental enamel hypoplasia and nail dystrophy were observed. Case report. A 43-year-old patient, with a history of APS-1 syndrome, was admitted to the hospital because of exacerbation of candidiasis of the mucous membranes of the mouth. Additionally, dystrophy of the nails and the dental enamel, generalized alopecia and extensive vitiligo were observed. Due to antifungal treatment partial clinical improvement was achieved. Conclusions. APS-1 is a potentially life-threatening complex set of symptoms. Consistent treatment and strict follow-up of patients with this syndrome are necessary. [ABSTRACT FROM AUTHOR]

Introduction. Cutaneous anaplastic large cell lymphoma (C-ALCL) is one of the CD30+ lymphoproliferative disorders. Usually it has a mild course and does not require aggressive treatment. The prognosis in C-ALCL is good, with the 10-year survival rate reaching 90% of patients. Spontaneous remissions of the disease are possible. Objective. To present a patient with recurrent Hodgkin’s disease, in whom primary cutaneous anaplastic large cell lymphoma was diagnosed. Case report. A 35-year old woman with recurrent Hodgkin’s disease was admitted to the department for diagnosis and treatment of skin lesions, which appeared a few weeks ago. Primary cutaneous T-cell lymphoma was diagnosed by histopathology and immunohistochemistry. After two weeks spontaneous regression of skin lesions was observed. Conclusions. Larger diagnostic procedures and exclusion of the systemic form of ALCL, cutaneous metastases of Hodgkin’s disease and large-cell transformation of mycosis fungoides are required due to the aggressive course and different treatment in all cases. [ABSTRACT FROM AUTHOR]

Introduction. Factors provoking pemphigus foliaceus are drugs, ultraviolet light, radiotherapy or skin damage. Association of pemphigus with malignancy is still controversial. Objective. To present a patient after resection of skin cancer with metastasis to regional lymph nodes, in whom pemphigus foliaceus had developed. Case report. A 76-year-old patient after resection of a tumor (carcinoma adnexogenes probabiliter trichoides) was admitted to our department a few days after the procedure, within the postoperative wound, itchy erythematous-exfoliating skin lesions appeared. Contact dermatitis was diagnosed. The gradual generalization of lesions led to further investigations. Based on the immunological and immunopathological tests the diagnosis of pemphigus foliaceus was confirmed. Azathioprine was introduced, with gradual improvement. On the 10th day of treatment the patient's general condition worsened. Immunosuppressive therapy was discontinued and antibiotics were introduced. Palliative treatment was carried out in a hospice. Conclusions. Coexistence of malignancy and pemphigus causes therapeutic difficulties and requires a careful approach. [ABSTRACT FROM AUTHOR]

Introduction. Acne fulminans is the most severe form of acne. It occurs predominantly in boys in the peripubertal period. Skin lesions are accompanied by general symptoms and laboratory abnormalities. Objective. Presentation of a patient with acne vulgaris in whom after 6 weeks of treatment with isotretinoin a rapid exacerbation of acne lesions occurred. Case report. A 38-year-old patient with a history of acne was admitted to the department due to severe symptoms of acne with associated fever, loss of weight and muscle and joint pain, which developed during isotretinoin therapy. Laboratory tests showed anemia and increased inflammatory markers. After administration of systemic glucocorticosteroids partial local improvement and regression of general symptoms were achieved. Addition of isotretinoin again caused pain of spine. After therapy with lymecycline a clinical improvement was achieved. Conclusions. Acne fulminans is a rare complication of therapy with isotretinoin. Due to the coexistence of systemic symptoms and risk of disfiguring scars, early diagnosis and introduction of appropriate treatment are required. [ABSTRACT FROM AUTHOR]

Copyright of Dermatology Review / Przeglad Dermatologiczny is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. Psoriasis is a chronic, inflammatory and proliferative skin diseasewith a complex pathogenesis. Associations between psoriasis and various systemic and skin disorders have been reported. In the literature, there are also a few reports of coexistence of bullous pemphigoid with psoriasis. Objective. The aimof this paper was to present a patient with psoriasis, inwhom, after topical application of altacet (aluminumacetotartrate) bullous pemphigoid developed. Case report.We present a case of 63-year-old patient with 4-month history of psoriasis, inwhomafter chronic topical treatmentwith high-potency corticosteroids, exacerbation of skin lesions with tendency to erythroderma occured. During the hospitalization generalized inflammation of the skin and appearance of numerous pustules were observed. Laboratory tests revealed increase in concentrations ofmarkers of inflammation. Oral antibiotic and neutral moisturizing topical treatment were administered. In the following days swelling of the dorsa of the hands and feet were observed onwhich compresseswith altacet were applied. The next day tense blisters were observed, initially on the skin of the hands and feet, then on the trunk and upper and lower extremities. Immunological test of serumconfirmed the diagnosis of bullous pemphigoid. After systemic (antibiotic and acitretin) and topical treatment receding of skin lesions was observed. Conclusions. In the presented case chronic topical glicocorticosteroid therapy caused erythrodermic formof psoriasis. Due to the swelling of hands and feet compressess with altacet were applied which provoked bullous pemphigoid, confirmed immunologically. Pathogenetic link between this two diseases remains unclear. Coexistence of psoriasis and pemphigoid may cause the therapeutic difficulties and requires careful therapeutic approach. [ABSTRACT FROM AUTHOR]

Introduction. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a serious, potentially life-threatening syndrome with skin lesions, fever, internal organ involvement and eosinophilia. Objective. To present the case of a woman with DRESS syndrome after the anticonvulsant drug lamotrigine. Case report. A woman, 25 years old, suffering from epilepsy, was admitted to the hospital after the change of valpromic acid to lamotrigine, which caused generalized maculopapular eruptions and laboratory blood test abnormalities. After withdrawal of the causative drug and treatment with corticosteroids and antihistaminic preparations, skin lesions disappeared and the values of laboratory blood tests improved. Conclusions. Due to the high rate of mortality (10%) in DRESS, a quick diagnosis is of crucial value. Most important is a detailed anamnesis, immediate withdrawal of the causative drug, and in severe cases therapy with systemic corticosteroids. [ABSTRACT FROM AUTHOR]