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A study conducted by researchers at South China Normal University in Guangzhou, China, explores the use of aerobic granular sludge (AGS) for the treatment of swine wastewater. Swine wastewater contains high levels of pollutants, antibiotics, and antibiotic resistance genes (ARGs), which require effective elimination. The study found that AGS reactors showed promising results in removing antibiotics, particularly sulfonamides, from the wastewater. Process optimization, including the introduction of an additional anoxic phase, improved denitrification and reduced ARG levels. The study provides valuable insights into the application of AGS for real swine wastewater treatment. [Extracted from the article]

A study conducted by researchers at Sun Yat-sen University in Guangzhou, China, explores the role of RNA modifications in cancer development. Specifically, the study focuses on the RNA ac4C 4 C modification, also known as N4-acetylcytidine, and its influence on various stages of the RNA lifecycle. The researchers discuss the molecular mechanisms and biological functions of this modification and its impact on the pathogenesis and progression of cancer. They also highlight the potential for manipulating this modification as a novel therapeutic strategy for more effective cancer treatments in the future. The study has been peer-reviewed and provides an integrated overview of current methodologies for detecting RNA ac4C 4 C modification. [Extracted from the article]

Researchers at Guangzhou University in China have developed a new photocatalytic hydrogel system for removing oxytetracycline (OTC) from wastewater. OTC is an antibiotic that poses environmental risks due to its persistence in ecosystems. The hydrogel, called CA-BiOBr 0.75 I 0.25 , demonstrated rapid adsorption and achieved a 90.92% degradation rate of OTC within 60 minutes under visible light. The system also showed excellent stability and reusability. This research highlights the potential of the hydrogel as a sustainable solution for advanced wastewater treatment technologies. [Extracted from the article]

Researchers at South China Agricultural University have discovered that trans-cinnamaldehyde, a compound found in cinnamon, can effectively inhibit the growth of multidrug-resistant Escherichia coli (E. coli) by disrupting the integrity of its cell wall. The compound causes an imbalance between lipopolysaccharide (LPS) and phospholipids in the cell wall, leading to structural changes and the leakage of proteins and DNA/RNA. This ultimately results in the death of the bacteria. The findings suggest that trans-cinnamaldehyde could be a potential drug candidate for preventing and treating infectious diseases caused by resistant E. coli strains. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-sen University in Guangzhou, China, has found that a novel gold-based complex called GC7 has the potential to suppress cancer cell proliferation by impacting energy metabolism mediated by mitochondria. The researchers synthesized and evaluated GC7 in various cancer cell lines and found that it exhibited a broad-spectrum anticancer effect, with greater potency than the gold-based compound auranofin. GC7 was shown to induce apoptosis in cancer cells, inhibit cellular thioredoxin reductase activity, suppress mitochondrial oxygen consumption rate, reduce glucose uptake, and possibly suppress glycolysis. Animal models also demonstrated the tumor-suppressing effects of GC7. The study suggests that GC7 could be a promising candidate for cancer therapy. [Extracted from the article]

A recent report from Guangzhou University of Chinese Medicine discusses the development of a potential therapeutic strategy for hepatocellular carcinoma, a common and fatal form of liver cancer. The researchers focused on using dihydroartemisinin (DHA), a derivative of artemisinin, to target mitochondria and induce apoptosis in cancer cells. They created carrier-free nanoparticles that delivered DHA to the tumor site, increasing intracellular reactive oxygen species and mitochondrial stress. In vivo experiments showed promising anti-tumor effects. This research provides insight into a potential treatment option for hepatocellular carcinoma. [Extracted from the article]

Researchers from Guangdong Pharmaceutical University in Guangzhou, China have discovered a new water-soluble polysaccharide called PF90-1, derived from the fibrous root of Pseudostellaria heterophylla. PF90-1 has been found to have anti-inflammatory and antioxidant properties, as it inhibits nitric oxide production and reduces the levels of pro-inflammatory factors. The researchers suggest that PF90-1 could potentially be used as a therapeutic treatment for inflammatory and oxidative injuries. This research has been peer-reviewed and published in the journal Natural Product Research. [Extracted from the article]

Researchers from South China University of Technology have conducted a study on the use of metal-organic frameworks (MOFs) for drug delivery enhancement in cancer treatment. The study focused on the elimination of gelation, a common issue in the dissolution of co-amorphous (COAM) systems. The researchers used a Zr-based MOF called nanoUiO-67 as a drug carrier for the anti-cancer drug gefitinib (GTB) and co-former saccharin (SAC). The study demonstrated the potential of this strategy in gelation elimination and the development of multi-component drug-loaded MOFs. The research has been peer-reviewed and published in the Chemical Engineering Journal. [Extracted from the article]

Researchers at the South China University of Technology have developed composite nanofibers that can efficiently deliver the compound quercetin to the colon and achieve sustained release. Quercetin is known for its multiple biological activities and potential anticancer properties. The nanofibers, which were coated with pH-responsive shellac on hydrophilic gelatin, demonstrated high stability in the upper gastrointestinal tract and released quercetin in the colon after oral administration. In vitro and in vivo studies confirmed the enhanced anticancer activity of the composite nanofibers. The researchers believe that this system could also be used to deliver other bioactives to the colon and exert their functional effects. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-sen University in Guangzhou, China, aimed to identify potential drug targets for myopia. The study utilized Mendelian randomization to assess the effect of pharmacologically targetable genes on the risk of myopia. The researchers identified six potential genetically causal targets for myopia, including CD34, CD55, Wnt3, LCAT, BTN3A1, and TSSK6. Functional analysis suggested that pathways involved in dopaminergic neuron differentiation, cell adhesion, Wnt signaling, and plasma lipoprotein may be implicated in myopia pathogenesis. The study provides new insights into the development of therapeutic interventions for myopia and a better understanding of its underlying mechanisms. [Extracted from the article]

A recent study conducted at the University of Jinan in Guangzhou, China, has developed a core/shell hydrogel with multiple effects for the treatment of osteosarcoma-associated bone defects. The hydrogel is designed to first target and remove residual tumor cells and prevent bacterial infection, and then promote osteogenesis. The hydrogel achieves this through the use of a thermo-sensitive release of doxorubicin (DOX) and photothermal therapy (PTT), as well as the synergy of liquid crystal hydrogel and mild hyperthermia and ion effects. This research provides valuable insights for the development of materials for bone repair in osteosarcoma patients. [Extracted from the article]

A study conducted by researchers at Sun Yat-sen University in Guangzhou, China, has found that minocycline, a broad-spectrum tetracycline antibiotic, may have potential in treating retinitis pigmentosa (RP). The study showed that minocycline therapy effectively restored retinal function and structure in mice with RP, and inhibited the activation of microglia. The researchers also found that minocycline modulated mitochondrial homeostasis, reducing levels of mitochondrial reactive oxygen species and providing protection against photoreceptor degeneration. These findings have significant implications for the development of potential therapeutic strategies for RP. [Extracted from the article]

A report from the University of Jinan in Guangzhou, China discusses the importance of improving the mechanical properties of microneedles (MNs) for efficient drug delivery and therapeutic purposes. The review analyzes the factors that affect the mechanical properties of MNs, such as the physicochemical properties of the polymer, formulation compositions, and geometric parameters. The researchers suggest that the mechanical strength of MNs can be enhanced by adjusting the crosslinking density, crystallinity degree, and molecular weight of the polymer, as well as introducing polysaccharides and nano-microparticles as reinforcements. The review aims to provide guidance on fabricating MNs with robust mechanical strength for successful transdermal drug delivery. [Extracted from the article]

A recent report from Southern Medical University in Guangzhou, China discusses the use of multi-gene single nucleotide polymorphism (SNP) detection in gastric cancer using an ion semiconductor sequencing platform. Gastric cancer is a common type of tumor, often diagnosed at an advanced stage requiring chemotherapy. The study highlights the importance of individualized treatment and the role of pharmacogenetics in guiding clinical implementation. The ion torrent next-generation semiconductor sequencing technology is a promising tool for rapidly detecting gastric cancer-related SNPs, allowing for personalized chemotherapy. The technique is cost-effective, requires low sample amounts, and has fast sequencing speed. [Extracted from the article]

Researchers from Sun Yat-sen University in Guangzhou, China have conducted a study on the therapeutic effects of motor-cognitive dual task and scalp acupuncture. The study aimed to demonstrate the standardized operation of scalp acupuncture synchronizing motor-cognitive dual task and compare the differences between these two tasks in healthy subjects. The research found that scalp acupuncture synchronizing motor-cognitive dual task may have a positive influence on cognitive performance, gait control, and cortical brain function. This study provides new ideas and a theoretical basis for the exploration of non-drug treatments in integrated Chinese and Western medicine. [Extracted from the article]

A new report from Sun Yat-sen University in Guangzhou, China discusses the use of a microbubble to enhance therapy for gliomas, a type of brain tumor. The microbubble is designed to bind to low-density lipoprotein receptors on brain capillary endothelial cells, allowing it to penetrate the blood-brain barrier and deliver drugs directly to the tumor site. The microbubble was found to be effective in inhibiting tumor growth in mice without causing significant brain damage. This research offers promising opportunities for improved intracranial drug delivery against gliomas. [Extracted from the article]

A study conducted by researchers at Sun Yat-sen University in Guangzhou, China, explores the use of Fe-nanocluster embedded biomass-derived carbon for efficient water purification. The researchers found that the Fe/Bio-C catalysts achieved a high efficiency of 98.6% in removing the quinolone antibiotic lomefloxacin within 30 minutes. The study also investigated the influence of reaction parameters on degradation performance, kinetics, toxicity, and mechanism. The research concludes that this work expands the possibilities for constructing metal-nanocluster photocatalysts with high reactivity and low metal leaching for various pollutants. [Extracted from the article]

Researchers from Guangdong Pharmaceutical University in Guangzhou, China have conducted a study on the anticancer activity of cyclometalated iridium(iii) compounds. The compounds were found to have strong cytotoxicity against lung cancer cells, specifically A549 cells. The study also investigated the mechanism of antitumor activity and found that the compounds induced apoptosis of the cancer cells through a mitochondrial pathway. The results suggest that these compounds could be potential chemotherapeutic agents for photodynamic therapy of lung cancer. The research was supported by the National Natural Science Foundation of China. [Extracted from the article]

A recent report from Sun Yat-sen University in Guangzhou, China discusses the dosing strategy of Tacrolimus (TAC) when co-administered with Wuzhi tablet in renal transplant recipients. TAC is an immunosuppressant used to prevent allograft rejection, and Wuzhi tablet is commonly used in China as a TAC-sparing agent. The study conducted population pharmacokinetic modeling and found that factors such as CYP3A5 genotype, weight, hematocrit, and the use of Wuzhi tablet influenced the clearance of TAC. The researchers recommend an initial dose of TAC when co-administered with Wuzhi tablet, which could help guide individualized regimens for renal transplant patients. [Extracted from the article]

A study conducted by researchers at Sun Yat-sen University in Guangzhou, China, has found that dihydromyricetin (DHM), a flavonoid from vine tea, has potential benefits for treating diabetic renal fibrosis. The researchers discovered that DHM effectively suppressed the synthesis of fibrotic and inflammatory adhesion factors in diabetic mice and glomerular mesangial cells. They also found that DHM reduced the activity and protein expression of sphingosine kinase-1 (SphK1), a key regulator of diabetic renal inflammation, which ultimately inhibited the activation of the NF-xB pathway. The study suggests that DHM could be a potential candidate for treating diabetic renal fibrosis. [Extracted from the article]

A recent study conducted by researchers at the South China University of Technology in Guangzhou, China, has developed a smart dressing for infected skin wound repair. The dressing, created using in-situ electrospinning technology, contains copper peptide (GHK-Cu) and quaternium-73 (Pionin) dual-drugs. The dressing demonstrated biocompatibility, antibacterial, anti-inflammatory, and tissue regenerative properties. It promoted wound healing by releasing the drugs, promoting cell proliferation, and reducing inflammation. The study suggests that this smart dressing could be clinically applied to complicated skin wound healing. [Extracted from the article]

Researchers from the University of Jinan in Guangzhou, China, have developed a series of 5-amino-1 H-pyrazole-4-carboxamide derivatives as novel pan-FGFR covalent inhibitors for the treatment of various cancers. These inhibitors target both wild-type and gatekeeper mutant FGFRs, addressing the issue of drug resistance. The representative compound 10h demonstrated strong activity against FGFRs and effectively suppressed the proliferation of lung and gastric cancer cells. The study provides a promising avenue for the development of anticancer drugs targeting FGFRs. [Extracted from the article]

Researchers at Sun Yat-sen University in Guangzhou, China have developed a double-click strategy for constructing chemical libraries in drug discovery. This strategy enables the sequential ligations of carboxylic acids and amines with fluorosulfuryl isocyanate (FSO2NCO) through a modular amidation/SuFEx process. The method provides easy access to chemical libraries of N-fluorosulfonyl amides and N-acylsulfamides in high yields. Preliminary screening of the compounds synthesized using this strategy has shown high antimicrobial activity against Gram-positive bacterium S. aureus and drug-resistant MRSA. This research highlights the potential application of modular click chemistry libraries in high-throughput medicinal chemistry. [Extracted from the article]

Researchers at Southern Medical University in Guangzhou, China have discovered potential new strategies for treating hepatic sepsis, a condition that can quickly result in fatality for critically ill individuals. The researchers identified PDE4 as a potential target for the treatment of liver damage associated with sepsis. They discovered a novel PDE4 inhibitor, 4e, which demonstrated better inhibitor activity and improved oral bioavailability compared to existing compounds. In animal models, 4e exhibited excellent hepatoprotective activity against hepatic sepsis. This research provides valuable insights for the development of new drugs to treat sepsis. [Extracted from the article]

A recent study conducted by Guangzhou Medical University in China has reported a novel finding in the treatment of lung adenocarcinoma. The study focused on a patient with HER2 exon 20 insertion lung adenocarcinoma who had previously failed multiple treatments. The researchers discovered that sunvozertinib, a small molecule tyrosine kinase inhibitor, stabilized the patient's condition and achieved a progression-free survival of 87 days. This finding may provide new treatment options for HER2 exon 20 insertion patients who have failed previous therapies. The research has been peer-reviewed and published in the journal Anti-Cancer Drugs. [Extracted from the article]

A report from the University of Jinan in Guangzhou, China discusses the use of exosome-biomimetic nanocarriers for oral drug delivery. Exosomes are nanovesicles secreted by living cells that can facilitate intercellular communication and drug delivery. The researchers reviewed the biogenesis and functions of exosomes, extraction and characterization methods, and the design of exosome-derived vehicles for oral drug delivery. The study concludes that exosome-biomimetic nanocarriers show promise for delivering difficult-to-administer drugs orally. This research has been peer-reviewed and published in Chinese Chemical Letters. [Extracted from the article]

A recent study conducted by researchers at the University of Jinan in Guangzhou, China, explores the use of selenium nanoparticles (SeNPs) as dual-functional agents for combating methicillin-resistant Staphylococcus aureus (MRSA) infection. The researchers engineered the surface chemistry of the SeNPs using different surfactants and found that the surface chemistry greatly influenced the bioactivities of the nanoparticles. The study demonstrated that the functionalized SeNPs exhibited strong inhibitory efficacy against MRSA by inducing robust reactive oxygen species (ROS) generation and damaging the bacterial cell wall. Additionally, the SeNPs were found to activate natural killer (NK) cells and enhance the phagocytic capability of macrophages, effectively combating MRSA infection and promoting wound healing in a mouse model. This research suggests that functionalized SeNPs could serve as effective antibacterial agents and guide the development of next-generation antibacterial treatments. [Extracted from the article]

A new study conducted by investigators at Guangzhou University of Chinese Medicine in China has reported findings on antioxidants. The study focused on Eucommiae Cortex (Duzhong), a plant used in traditional medicine, and aimed to update its quality-marker in Pharmacopoeias. The researchers used advanced analytical techniques to identify and quantify compounds in Eucommiae Cortex, and found that certain compounds, such as chlorogenic acid, had significant antioxidant properties. These findings have implications for updating the quality standards of Eucommiae Cortex in Pharmacopoeias. [Extracted from the article]

A recent study conducted by researchers at Sun Yat-sen University in Guangzhou, China, has identified a potential mechanism for gemcitabine resistance in nasopharyngeal carcinoma (NPC). The study found that a long non-coding RNA called DYNLRB2-AS1 was upregulated in gemcitabine-resistant NPC cell lines and promoted resistance to the chemotherapy drug. DYNLRB2-AS1 was shown to bind to the DHX9 protein and prevent its degradation, leading to increased DNA damage repair and cell proliferation. The researchers suggest that DYNLRB2-AS1 could serve as a prognostic biomarker and therapeutic target for overcoming gemcitabine resistance in NPC. [Extracted from the article]

A recent study conducted by researchers at the University of Jinan in Guangzhou, China, explored the antidepressant effects of Xiaoyaosan (XYS), a traditional Chinese medicine formulation used in the treatment of depression. The study identified 1813-glycyrrhetinic acid (1813-GA) as the primary compound responsible for the antidepressant effects of XYS in the brain. Through various methodologies, the researchers found that 1813-GA activates the brain-derived neurotrophic factor (BDNF) transcription, which is associated with the antidepressant-like effects of XYS. The findings suggest that the activation of BDNF transcription in the medial prefrontal cortex underlies the antidepressant effects of 1813-GA. [Extracted from the article]

Researchers at Guangzhou Medical University in China have conducted a study on the potential of Traditional Chinese Medicines (TCM) in combating drug-resistant Staphylococcus aureus (S. aureus). The study used molecular dynamics simulations to analyze the interactions between TCM compounds and the NorA protein, which is involved in drug resistance. The compounds piperine, demethoxycurcumin, and tectorigenin showed potential inhibitory activity against NorA, forming hydrogen bonds and hydrophobic contacts with key ionizable residues. This research provides insights into the potential of TCM in addressing drug resistance in S. aureus. [Extracted from the article]

Researchers at South China University of Technology have published a report on a chemoselective epoxidation strategy for electron-deficient olefins. The process involves a conjugated olefin epoxidation and BHT hydroxylation to produce various oxiranes, particularly 2-substituted 2-trifluoromethyloxiranes, in high yields. The protocol is mild, transition-metal free, operationally simple, and scalable, and it can accommodate diverse functional groups. The researchers also synthesized a drug candidate, HSD-16, using this method. Mechanism studies suggest that molecular oxygen serves as the terminal oxidant and the O-source for the oxiranes. [Extracted from the article]

A report from Guangzhou Medical University in China discusses research on cerebral hemorrhage, a type of brain injury. The study focuses on the role of a protein called thioredoxin-reductase 2 (Txnrd2) in reducing brain damage caused by intracerebral hemorrhage (ICH). The researchers found that Txnrd2 inhibits oxidative stress and endoplasmic reticulum (ER) stress through the Trx2/prx3 pathway. They also discovered that selenium supplementation can enhance Txnrd2 expression and protect against brain damage. This research highlights the potential of Txnrd2 as a therapeutic target for ICH. [Extracted from the article]

A recent study conducted at Sun Yat-sen University in Guangzhou, China, examined the efficacy of adjuvant chemotherapy (AC) in patients with different levels of Epstein-Barr virus (EBV) DNA plasma loads for nasopharyngeal carcinoma (NPC). The study included 675 patients diagnosed with stage III-IVa NPC, and the primary endpoint was progression-free survival (PFS). The results showed that patients with detectable mid-radiotherapy (mid-RT) EBV DNA had worse 5-year PFS than those with undetectable mid-RT EBV DNA. However, AC was found to be effective in reducing the risk of disease progression in patients with detectable mid-RT EBV DNA. [Extracted from the article]

Researchers from Southern Medical University in Guangzhou, China have developed a new approach to cancer therapy using a bimetallic electro-sensitizer called Pt-Ir NPs. This electro-sensitizer, loaded with the autophagy inhibitor chloroquine, enhances the effectiveness of electrotherapy by inhibiting autophagy and activating anti-tumor immune responses. The study found that this novel electrotherapy platform shows promise in treating hypoxic and immunosuppressive tumors by catalyzing water molecules into reactive oxygen species (ROS) under an electric field, inhibiting protective autophagy, and enhancing the functionality of immune cells. This research provides a new approach for the ablation and long-term inhibition of solid tumors through flexible modulation by an exogenous electric field. [Extracted from the article]

Researchers from Guangdong Pharmaceutical University in Guangzhou, China have conducted a study on the therapeutic effects of the Zhuangyao Jianshen pill (ZYJSP) against benign prostatic hyperplasia (BPH) in rats. The study found that ZYJSP effectively reduced prostate weight and ameliorated histological changes in the prostate. It also regulated sex hormone balance, reduced oxidative stress, and inhibited the inflammatory response. These findings suggest that ZYJSP may be a potential treatment for BPH. The study has been peer-reviewed and published in the Journal of Traditional Chinese Medicine. [Extracted from the article]

Researchers from South China Agricultural University have discovered a highly effective inhibitor of the type III secretion system (T3SS) in the foodborne pathogen Pseudomonas aeruginosa. The compound, called II-22, was found to specifically target the T3SS of P. aeruginosa and inhibit the secretion of the effector protein ExoS. It also suppressed the transcription of genes involved in bacterial virulence and enhanced the bactericidal activity of antibiotics. These findings could contribute to the development of novel antimicrobial drugs to combat bacterial resistance. The research has been peer-reviewed and published in the Journal of Agricultural and Food Chemistry. [Extracted from the article]

A new report from researchers at the South China University of Technology explores the use of salt hydrates and co-amorphous systems (COAMs) in modifying the properties of pharmaceutical drugs. The study found that water molecules play a crucial role in stabilizing salt hydrate systems by reducing energy and establishing hydrogen bonds. The researchers also discovered that COAMs can be formed in the absence of water through ball milling and quench cooling. These findings provide valuable insights into the formation of salt hydrates and COAMs and highlight the importance of controlling the presence of water. [Extracted from the article]

Researchers from Guangzhou Medical University have conducted a study on the effects of rehmannioside A (ReA) on systemic lupus erythematosus (SLE). They obtained SLE-related targets from databases and ReA-related targets from other sources. Through molecular docking and molecular dynamics simulation, they found that ReA exerts its effects on SLE through multiple targets and pathways, with mTOR being a key target. The study provides insights into the potential mechanisms of ReA in the treatment of SLE. This research has been peer-reviewed and published in Cell Biochemistry and Biophysics. [Extracted from the article]

Researchers from the University of Jinan in Guangzhou, China, have developed a neutrophil-mimicking nanozyme for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The nanozyme, called MGBC, has high delivery efficiency and self-supplies hydrogen peroxide (H2O2) to generate highly active signet oxygen (O-1(2)). It also releases nitric oxide (NO) for gas therapy, resulting in a synergistic bimodal therapy that effectively kills MRSA and eradicates MRSA biofilms. The research found that the nanozyme downregulates genes related to drug resistance, toxicity, and biofilm formation in MRSA. This study provides insights into the development of new treatments for MRSA infections. [Extracted from the article]

Researchers at Sun Yat-sen University in Guangzhou, China have developed a new method for encapsulating siRNA (small interfering RNA) in nanogels without the use of cationic materials. This approach addresses the limitations of current cationic materials, such as toxicity and limited shelf-life. The nanogels created through this method have pH-responsiveness and enzyme sensitivity, allowing for charge reversal, endo/lysosomal escape, and controlled release of siRNA. The efficiency of the nanogels for siRNA delivery and gene inhibition has been confirmed through experiments. This research provides a feasible platform for siRNA delivery that is free of cationic toxicity. [Extracted from the article]

A research report from Sun Yat-sen University in Guangzhou, China discusses the development of dual-target drugs for complex diseases such as cancers and autoimmune disorders. The researchers propose a method called AIxFuse, which uses artificial intelligence and molecular simulation to learn and generate molecules that satisfy the structural constraints of two targets. AIxFuse outperforms other methods in generating dual-target drugs and shows promising binding free energies against both targets. The research concludes that AIxFuse learns to fuse pharmacophores through collaborative learning. [Extracted from the article]

A recent study conducted by researchers at the University of Jinan in Guangzhou, China, explored the efficacy of Chang-Kang-Fang (CKF), a traditional Chinese medicine, in treating diarrhea-predominant irritable bowel syndrome (IBS-D). The study utilized a rat model of IBS-D and found that CKF treatment reduced symptoms such as visceral hypersensitivity and diarrhea severity. Additionally, CKF was found to inhibit the Toll-like receptor 4/Nuclear factor kappa-B/NLR family pyrin domain-containing protein 3 (TLR4/NF-kappa B/NLRP3) pathway, which may contribute to its therapeutic effects. The study also identified several potential bioactive components in CKF that could be further explored for the treatment of IBS-D. [Extracted from the article]

Researchers from Sun Yat-sen University in Guangzhou, China have conducted a study on cardiac hypertrophy, a condition characterized by an enlarged heart. They focused on a specific long noncoding RNA (lncRNA) called CARDINAL and its role in regulating protein translation in the heart. The researchers found that CARDINAL expression was induced during pathological cardiac hypertrophy and that its deletion exacerbated the condition, while overexpression attenuated hypertrophy. They concluded that targeting cardiac-specific lncRNAs like CARDINAL could be a potential therapeutic approach for treating cardiac hypertrophy and heart failure. [Extracted from the article]