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A recent study conducted in Chiba, Japan, explored the adsorption of daptomycin by a polymethylmethacrylate (PMMA) hemofilter in vitro. The research found that daptomycin was adsorbed and removed by the PMMA hemofilter, similar to teicoplanin. The study suggests that daptomycin administration via a PMMA hemofilter should be avoided during blood purification therapy. This research was supported by Grants-in-Aid for Scientific Research (KAKENHI) and has been peer-reviewed. [Extracted from the article]

Researchers at Ohio State University have conducted a study on the relationship between daptomycin (DAP) resistance and sensitivity to phage Sb-1 in clinical MRSA strains. The study found that the addition of bacteriophage to standard antibiotic therapies for multidrug-resistant Staphylococcus aureus infections could potentially hinder or revert antibiotic resistance. This research suggests that adjunctive treatment with phage in DAP-resistant strains may lead to synergistic activity and larger phage plaque sizes, ultimately preserving the efficacy of current antibiotics. Further validation in relevant models of infections is needed to confirm these findings. [Extracted from the article]

Researchers at Tohoku Medical and Pharmaceutical University in Sendai, Japan, conducted a study on the stability of daptomycin in icodextrin-based peritoneal dialysis solutions. The study found that daptomycin maintained 90% of its initial concentration in the solution for 72 hours at room temperature and 12 hours at 37°C. The research aims to enhance outpatient management and preparation for treating peritonitis using daptomycin. The findings were published in the Peritoneal Dialysis International journal by SAGE Publications. [Extracted from the article]

A study conducted at Islamia University Bahawalpur explored the combined effects of lipopeptides and methyl jasmonate in preventing gray mold in strawberry fruit caused by Botrytis cinerea. The research found that the application of lipopeptides and methyl jasmonate together resulted in the lowest lesion diameter and disease incidence in strawberries, enhancing the fruit's defense system through increased antioxidant activity. This study highlights the potential of Bacillus lipopeptides and methyl jasmonate in reducing postharvest spoilage in strawberries. [Extracted from the article]

A study conducted at the University of Liege in Belgium has found that ticagrelor, a drug known for its antiplatelet properties, also has antibacterial activity against Gram-positive bacteria, including drug-resistant strains of Staphylococcus aureus. The research revealed that ticagrelor alters the membrane of these bacteria, enhancing the effectiveness of conventional antibiotics like vancomycin and daptomycin without causing cross-resistance. This study sheds light on potential new treatment options for infections caused by multidrug-resistant bacteria. [Extracted from the article]

Researchers at CognoGen Biotechnology Consulting have published a new report on the regulation of daptomycin biosynthesis in Streptomyces roseosporus. Daptomycin is an antibiotic used to treat Gram-positive infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). The study analyzed the genome sequences of two strains of S. roseosporus and identified mutations in a promoter region that drives the transcription of genes involved in daptomycin biosynthesis. The findings suggest that manipulating this promoter region could improve daptomycin production and accelerate the development of new lipopeptide antibiotics. The research has been peer-reviewed and provides valuable insights for the field of synthetic biology. [Extracted from the article]

A study conducted at Hunan University in China has developed a new strategy to address the challenge of antibiotic resistance transmission. The researchers created virus-inspired lipopeptide-polymeric nanoblockers that impede the spread of antibiotic resistance from donor bacteria to recipient bacteria. These nanoblockers effectively internalize into drug-resistant bacteria, deliver natural products, and block the spread of resistant plasmids. The study demonstrated that pretreating donor bacteria with these nanoblockers preserved the antibiotic sensitivity of recipient bacteria and suppressed their growth. The researchers concluded that this nanomaterial-based strategy offers a safe and efficient solution to antibiotic resistance transmission. [Extracted from the article]

A recent study conducted at the Medical University of South Carolina aimed to understand the clinical characteristics and outcomes of using the antibiotic Daptomycin (DAP) in pediatric patients. The study included 40 patients under the age of 18 who were treated with DAP for various infections. The results showed that most patients achieved clinical success with a low incidence of adverse effects. However, larger studies are needed to further assess the clinical outcomes of DAP use in pediatric patients. [Extracted from the article]

A study conducted at a tertiary care hospital in Central India examined the susceptibility trends of clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates to commonly used anti-MRSA drugs. The study found that the minimum inhibitory concentration (MIC) of vancomycin, teicoplanin, and linezolid, which are standard antimicrobial drugs for MRSA, increased over the three-year period from 2020 to 2022. While none of the MRSA isolates were resistant to vancomycin, teicoplanin, and daptomycin, two isolates showed resistance to linezolid. The study suggests that the recovery of vancomycin-intermediate S. aureus (VISA), teicoplanin-intermediate S. aureus (TISA), and linezolid-resistant MRSA strains is concerning and may indicate potential treatment failure and the emergence of resistant strains. [Extracted from the article]

A study conducted in Cannes, France, explored the efficacy of antibiotic lock therapy (ALT) in treating long-term catheter-related bloodstream infections (CRBSI). The researchers used a combination of Daptomycin (DPT) and Taurolidine ALT, along with systemic antibiotic treatment (SAT), to manage coagulase-negative Staphylococci (CoNS) CRBSI. The study included 22 subjects with CoNS-associated CRBSI, with a success rate of 95% and a failure rate of 5%. The researchers concluded that short-course DPT as ALT, combined with SAT and Taurolidine ALT, allowed for successful conservative management of catheters in cases of CoNS-associated CRBSI. [Extracted from the article]

A recent study conducted at the University of Florida has found that vancomycin-resistant enterococci (VRE) commonly colonize the gut of individuals with hematologic malignancies or undergoing hematopoietic cell transplant (HCT) and may cause bacteremia. The study used whole-genome sequencing (WGS) and phylogenetic analyses to examine 82 clinical VRE strains isolated from patients with leukemia and HCT between 2015 and 2019. The researchers observed transmission of highly genetically related strains between rooms on the same or different floors, including a daptomycin-resistant (DR)-VRE strain identified in 2012. The study highlights the emergence and persistence of VRE strains, particularly DR-VRE, in the hospital and suggests that adding WGS to routine infection control measures may help identify potential horizontal VRE transmission, including multi-drug-resistant isolates. [Extracted from the article]

Daptomycin is a lipopeptide antibiotic used to treat serious Gram-positive infections, but its interaction with bacterial membranes is not well understood. This study found that the interaction occurs in two stages: a fast and reversible binding to the phospholipid membrane, followed by a slow and irreversible insertion into the membrane in the presence of the bacteria-specific lipid phosphatidylglycerol. The antibiotic forms a stable complex with calcium and phosphatidylglycerol, which can be easily isolated from the membrane of drug-treated bacterial cells. This discovery provides new insights into the mechanism of action of daptomycin and may lead to strategies to combat drug resistance. [Extracted from the article]

A recent study conducted at the Universidad de La Sabana focused on the development and characterization of antibodies for the monitoring of glycopeptide antibiotics. The researchers aimed to create new methodologies for Therapeutic Drug Monitoring (TDM) to improve patient outcomes and reduce healthcare costs. The study successfully developed antibodies capable of recognizing specific antibiotics, such as Vancomycin, Colistin, Daptomycin, and Meropenem, with good detectability. These antibodies offer a promising tool for precise and effective therapeutic monitoring, potentially enhancing treatment efficacy and patient safety. [Extracted from the article]

A recent research study conducted by the Faculty of Medicine has explored the use of antibiotic-containing carrier systems for sustained drug release. The study focused on a composite of b-TCP ceramic and ADA gelatin, which showed promising results in terms of mechanical properties and biodegradability. The researchers measured the dual release of daptomycin and BMP-2 over a period of 28 days and observed a release of daptomycin above the minimum inhibitory concentration by day 9. Additionally, low concentrations of BMP-2 were released from the composite. This study provides new insights into the potential use of these carrier systems in antiinfective therapies. [Extracted from the article]

Researchers at the University of Malaya in Kuala Lumpur, Malaysia have conducted a study on the antimicrobial and anti-biofilm properties of a lipopeptide biosurfactant (LB) derived from bacteria. The study found that LB exhibited antimicrobial and anti-biofilm effects on Enterococcus faecalis, a bacterium commonly found in root canal infections. The researchers concluded that LB could be used as a standalone irrigation solution or in conjunction with sodium hypochlorite (NaOCl) for root canal treatment. The study highlights the potential of LB as an environmentally friendly option for root canal treatment. [Extracted from the article]

A recent study conducted by researchers at the University of Georgia has found that defects in the pgsA gene contribute to increased membrane fluidity and cell wall thickening in Staphylococcus aureus, a bacterium that is often resistant to antibiotics. The study focused on daptomycin, a last-resort antimicrobial therapy used to treat infections caused by drug-resistant strains of S. aureus. The researchers discovered that mutations in the pgsA gene led to changes in the composition of the bacterial membrane, making it more resistant to daptomycin. These findings provide valuable insights into the mechanisms of antibiotic resistance in S. aureus and could potentially inform the development of new treatment strategies. [Extracted from the article]

Researchers from the Leibniz Institute of Plant Biochemistry have conducted a study on the antitumor potential of cyclic lipopeptides (CLPs) against human cervix adenocarcinoma HeLa cells. They tested 23 CLPs and found that compound 10 showed significant cytotoxic potential against the HeLa cell line. The study also indicated that compound 10 induced apoptosis in the HeLa cells through caspase activation. These findings suggest that compound 10 could be used as a basis for designing more effective CLPs as potential anticancer agents. [Extracted from the article]

A recent study conducted at Mansoura University in Egypt has developed a new method for determining the concentration of the antibiotic daptomycin in various samples. The method uses a cationic surfactant called cetyltrimethylammonium bromide (CTAB) to enhance the fluorescent signal of daptomycin, allowing for sensitive detection. The researchers found that the method was effective in determining daptomycin concentrations in commercial vials, water, and biological fluids with high accuracy. The proposed method is considered to be environmentally friendly, simple, and reliable. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the structural changes in a daptomycin-resistant strain of Staphylococcus aureus. The study found that mutations in the genes mprF, yycG, and pgsA were associated with daptomycin resistance. The resistant strain exhibited decreased phosphatidylglycerol levels, increased branched-chain fatty acids in its membrane lipids, increased membrane fluidity, and increased cell wall thickness. The study suggests that the pgsA gene contributes to daptomycin resistance by affecting membrane fluidity, cell wall thickness, and phosphatidylglycerol levels. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at East China Normal University in Shanghai, China, has identified a fluorous peptide amphiphile called R6F that exhibits potent antimicrobial activity against drug-resistant bacterial infections. The researchers synthesized a library of fluoro-lipopeptide amphiphiles and found that R6F, which contains six arginine moieties and a fluorous tag, demonstrated the highest antibacterial activity. R6F was able to permeabilize bacterial membranes, disrupt respiratory reactions and antioxidant defense systems, and destroy the peptidoglycan in cell walls. When formulated into lipid nanoparticles, R6F effectively treated MRSA-induced sepsis and chronic wound infections with minimal side effects. This research provides a novel strategy for designing highly potent antibacterial peptide amphiphiles. [Extracted from the article]

A study conducted at the University Hospital Salamanca in Spain has examined the genomic insights into Staphylococcus aureus isolates that exhibit diminished susceptibility to the antibiotic daptomycin. Daptomycin is an important therapeutic resource for multidrug-resistant gram-positive bacteria, but its mechanisms of action and resistance are not completely understood. The study found mutations in several genes associated with daptomycin resistance in clinical isolates of Staphylococcus aureus, with the mprF and cls1 genes showing high polymorphism. These findings suggest that daptomycin non-susceptibility in Staphylococcus aureus is achieved through different mutation combinations. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the interactions of Bacillus subtilis UptA, a putative C55-P flippase, with undecaprenyl phosphate (C55-P), membrane phospholipids, and lipopeptide antibiotics. The study found that UptA forms monomer-dimer equilibria and binds to ligands in a pH-dependent manner. It also showed that UptA interacts more favorably with C55-P and that lipopeptide antibiotics can intercept UptA function by out-competing the substrate for the protein binding site. This research provides insights into the substrate-binding specificity of UptA and its potential regulation by anionic phospholipids, which could contribute to the development of antibiotics targeting carrier lipid recycling. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent report from the University of Wisconsin School of Medicine and Public Health discusses the use of daptomycin, an antibiotic, in pediatric patients. The study found that daptomycin was safe and effective in treating serious infections caused by gram-positive bacteria in children under 13 years old. The research involved a retrospective chart review of adverse reactions and treatment outcomes in 147 pediatric patients who received at least one dose of daptomycin. The study found that while some patients experienced side effects such as loose stools and elevated liver enzymes, overall, daptomycin was well-tolerated in this population. [Extracted from the article]

A recent study conducted at Houston Methodist Hospital in Texas has found that the effectiveness of the antibiotic daptomycin in treating vancomycin-resistant Enterococcus faecium infections is threatened by the emergence of daptomycin non-susceptibility. Current methods for determining daptomycin minimum inhibitory concentrations (MICs) are unreliable. The study focused on the LiaX protein, which is essential for the cell envelope response to daptomycin. The researchers developed an enzyme-linked immunosorbent assay (ELISA) to detect LiaX levels and found that elevated levels were present in both daptomycin-resistant and daptomycin-susceptible strains of E. faecium. The detection of LiaX could potentially improve the accuracy of susceptibility testing and help anticipate therapeutic failure. [Extracted from the article]

A recent preprint abstract discusses the mechanisms of daptomycin resistance in Staphylococcus aureus, a bacterium that causes infections. Daptomycin is an important antibiotic used as a last resort when other treatments fail. The study found that mutations in specific genes, such as mprF, yycG, and pgsA, contribute to daptomycin resistance. The resistant strain showed changes in its cell envelope, including increased membrane fluidity and cell wall thickness. The researchers also discovered that supplementing the culture broth with certain fatty acids could partially reverse the resistance. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

A new study conducted at the University of New Mexico Health Sciences Center compared the outcomes of different treatment approaches for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, a serious infection associated with high mortality rates. The study found that dual therapy with ceftaroline did not reduce the risk of mortality compared to monotherapy with vancomycin or daptomycin. However, patients who received infectious diseases (ID) consultations showed a significant reduction in mortality rates. The researchers concluded that further large-scale, prospective, and randomized controlled trials are needed to determine the potential benefits of dual therapy with ceftaroline for MRSA bacteremia. [Extracted from the article]

A recent study conducted at University Hospital Asturias in Spain examined the incidence of acute kidney damage in patients treated with glycopeptide antibiotics, specifically vancomycin, linezolid, and daptomycin. The study found that 17.62% of patients developed renal failure, with vancomycin having an incidence rate of 14.74%, linezolid at 19.13%, and daptomycin at 30.59%. Risk factors for kidney damage included high creatinine and urea levels, duration of treatment, body mass index, ICU stay, age, and low CKDEPI and albumin levels. The study concluded that while vancomycin-associated nephrotoxicity remains a concern, linezolid and daptomycin can also cause kidney damage. Understanding these risk factors can lead to better management of patients taking these antibiotics. [Extracted from the article]

A recent study conducted by researchers at Ewha Womans University in Seoul, South Korea, has discovered a potential solution to the treatment challenges posed by Staphylococcus aureus infections, including methicillin-resistant S. aureus (MRSA). The study focused on a methylazanediyl bisacetamide derivative called MB6, which selectively targets MRSA membranes without observable resistance development. The researchers found that MB6 enhances the bactericidal activity of gentamicin and daptomycin, two commonly used antibiotics, against MRSA persisters. These findings suggest that MB6 could serve as a potent antimicrobial adjuvant to enhance the efficacy of existing antibiotics against persister cells. [Extracted from the article]

A study conducted by researchers at China Pharmaceutical University in Nanjing, China, has developed a liposomal delivery platform for the treatment of hypertrophic scars. Hypertrophic scars can cause functional impairment, pruritus, and pain, and require a transdermal drug delivery system that can penetrate the scar tissue. The liposomal delivery platform consists of dendritic lipopeptides that mimic viral protein transduction domains and can penetrate fibroblast membranes, promoting apoptosis and collagen fiber remodeling to remove raised scars. The research has been peer-reviewed and provides new insights into liposomes for scar treatment. [Extracted from the article]

A recent preprint abstract discusses the collateral effects of daptomycin-resistant E. faecalis, a type of bacteria that causes infections. Daptomycin is an antibiotic used to treat multi-drug-resistant infections, but little is known about how the bacteria's resistance to daptomycin affects its sensitivity to other drugs. The study found that mutations in certain genes associated with daptomycin resistance led to divergent responses to different antibiotics, particularly CRO. Additionally, mutations in another gene were associated with increased sensitivity to CRO and reduced growth rate. These findings highlight the complexity of bacterial evolution and the trade-offs between resistance and growth rates. [Extracted from the article]

A recent study conducted by researchers at the Birla Institute of Technology and Science in Goa, India, focused on Bacillus subtilis and its potential as an antifungal agent. The study investigated a lipopeptide called AF4 derived from Bacillus subtilis, which demonstrated broad-spectrum antifungal activity. The researchers found that AF4 primarily acts on the cell membrane of Candida albicans, a common infectious species of Candida. The study suggests that AF4 has the potential to be developed as an antifungal drug candidate. [Extracted from the article]

Researchers from the University of Utah have conducted a study on Gram-Negative Bacteria and published their findings. The study focused on the resistance mechanisms of Gram-negative bacteria-specific lipopeptides called turnercyclamycins, which differ from the resistance mechanisms of colistin, a last-line antibiotic. The researchers found that turnercyclamycins interact with the lipopolysaccharide (LPS) pathway and remain active against colistin-resistant clinical isolates. They also discovered that turnercyclamycin A showed greater effectiveness and resistance than turnercyclamycin B. The study suggests that turnercyclamycin A may have potential in treating drug-resistant infections. [Extracted from the article]

A study conducted by researchers at Justus-Liebig-Universitat Giessen in Germany has found that daptomycin, an antibiotic, shows promise in treating periprosthetic joint infections caused by vancomycin-resistant pathogens. The study investigated the mechanical stability, handling properties, elution behavior, and antimicrobial effectiveness of PMMA cement loaded with different concentrations of daptomycin. The results showed that PMMA cement with 1.5 g of daptomycin was the most effective in terms of elution and effectiveness. The researchers suggest that PMMA cement containing 0.5 g of gentamicin and 1.5 g of daptomycin could be a good alternative for the treatment of these infections. [Extracted from the article]

Researchers at General University Hospital Castellon in Spain have conducted a study on the stability of glycopeptide antibiotics, specifically vancomycin and daptomycin, in heparin or sodium citrate lock solutions. The aim of the study was to find the optimal combination of antimicrobials and additives for lock solutions to maximize patient safety. The researchers found that vancomycin and daptomycin combined with heparin retained at least 90% of the initial concentration over 48 hours, while vancomycin-sodium citrate solution stored at 37 degrees Celsius reduced more than 10% of the initial concentration at 24 hours. Daptomycin-sodium citrate combination was more stable for extended periods, but its bioactivity has not been demonstrated. The findings suggest that vancomycin and daptomycin lock solutions combined with heparin should be changed at 48 hours, with stability over 3 days at 25 degrees Celsius and 7 days at 4 degrees Celsius. [Extracted from the article]

Single therapies were not bactericidal when evaluated in the 168 h in vitro one-compartment model with an initial inoculum of 109; however, the combination of DAL plus single dose of DAP resulted in enhanced killing at the end of the 168-h exposure. Keywords: Detroit; State:Michigan; United States; North and Central America; Antibiotics; Antiinfectives; Bacterial Infections and Mycoses; Cyclic Peptides; Dalbavancin Therapy; Dalvance Therapy; Daptomycin Therapy; Drugs and Therapies; Glycopeptide Antibiotics; Glycopeptides Therapy; Gram-Positive Bacteria; Health and Medicine; Lipopeptides; Peptides; Pharmaceuticals; Staphylococcus aureus; Vancomycin Therapy EN Detroit State:Michigan United States North and Central America Antibiotics Antiinfectives Bacterial Infections and Mycoses Cyclic Peptides Dalbavancin Therapy Dalvance Therapy Daptomycin Therapy Drugs and Therapies Glycopeptide Antibiotics Glycopeptides Therapy Gram-Positive Bacteria Health and Medicine Lipopeptides Peptides Pharmaceuticals Staphylococcus aureus Vancomycin Therapy 1174 1174 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Gram-Positive Bacteria - Staphylococcus aureus. [Extracted from the article]

Antibiotics, Antiinfectives, Cyclic Peptides, Daptomycin Therapy, Drugs and Therapies, Health and Medicine, Lipopeptides, Peptides, Pharmaceuticals, Risk and Prevention Keywords: Antibiotics; Antiinfectives; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Health and Medicine; Lipopeptides; Peptides; Pharmaceuticals; Risk and Prevention EN Antibiotics Antiinfectives Cyclic Peptides Daptomycin Therapy Drugs and Therapies Health and Medicine Lipopeptides Peptides Pharmaceuticals Risk and Prevention 2544 2544 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on antiinfectives is now available. [Extracted from the article]

In the meta-analysis, statin use significantly increased the incidence of DAP-related rhabdomyolysis (odds ratio [OR]: 3.83; 95% confidence interval [CI]: 1.43-10.26) but not DAP-related myopathy (OR: 1.72; 95% CI:.95-3.12). Keywords: Tokushima; Japan; Asia; Adverse Drug Reactions; Antibiotics; Antiinfectives; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Health and Medicine; Lipopeptides; Muscular Diseases and Conditions; Musculoskeletal Diseases and Conditions; Myopathy; Nephrology; Peptides; Pharmaceuticals; Rhabdomyolysis EN Tokushima Japan Asia Adverse Drug Reactions Antibiotics Antiinfectives Cyclic Peptides Daptomycin Therapy Drugs and Therapies Health and Medicine Lipopeptides Muscular Diseases and Conditions Musculoskeletal Diseases and Conditions Myopathy Nephrology Peptides Pharmaceuticals Rhabdomyolysis 2325 2325 1 10/16/23 20231020 NES 231020 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on Musculoskeletal Diseases and Conditions - Rhabdomyolysis are discussed in a new report. [Extracted from the article]

Many HHD regimens are used clinically, this study modeled ten common HHD regimens and determined optimal vancomycin and daptomycin dosing for each HHD regimen. Keywords: Antibiotics; Antiinfectives; Cyclic Peptides; Daptomycin Therapy; Dialysis; Drugs and Therapies; Glycopeptide Antibiotics; Glycopeptides Therapy; Health and Medicine; Hemodialysis; Home Hemodialysis; Lipopeptides; Peptides; Pharmaceuticals; Pharmacodynamics; Pharmacokinetics; Pharmacology; Vancomycin Therapy EN Antibiotics Antiinfectives Cyclic Peptides Daptomycin Therapy Dialysis Drugs and Therapies Glycopeptide Antibiotics Glycopeptides Therapy Health and Medicine Hemodialysis Home Hemodialysis Lipopeptides Peptides Pharmaceuticals Pharmacodynamics Pharmacokinetics Pharmacology Vancomycin Therapy 1996 1996 1 10/03/23 20231006 NES 231006 2023 OCT 6 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on home hemodialysis. Virtual vancomycin and daptomycin doses were administered post-HHD and drug exposures were determined in 5,000 virtual patients receiving ten different HHD regimens. [Extracted from the article]

Keywords: Lyon; France; Europe; Antibiotics; Antiinfectives; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Health and Medicine; Lipopeptides; Peptides; Pharmaceuticals EN Lyon France Europe Antibiotics Antiinfectives Cyclic Peptides Daptomycin Therapy Drugs and Therapies Health and Medicine Lipopeptides Peptides Pharmaceuticals 1108 1108 1 08/21/23 20230825 NES 230825 2023 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Drugs and Therapies - Antiinfectives. Lyon, France, Europe, Antibiotics, Antiinfectives, Cyclic Peptides, Daptomycin Therapy, Drugs and Therapies, Health and Medicine, Lipopeptides, Peptides, Pharmaceuticals. [Extracted from the article]

Keywords for this news article include: Baylor University, Antibiotics, Cell Wall, Lipopeptides, Cyclic Peptides, Daptomycin Therapy, Cellular Structures, Drugs and Therapies. Antibiotics, Cell Wall, Cellular Structures, Cyclic Peptides, Daptomycin Therapy, Drugs and Therapies, Lipopeptides, Peptides Keywords: Antibiotics; Cell Wall; Cellular Structures; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Lipopeptides; Peptides EN Antibiotics Cell Wall Cellular Structures Cyclic Peptides Daptomycin Therapy Drugs and Therapies Lipopeptides Peptides 2505 2505 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on antibiotics are presented in a new report. [Extracted from the article]

The news reporters obtained a quote from the research from Rice University, "Indeed, inhibition of LiaFSR signaling has been suggested as a strategy to "resensitize" enterococci to DAP. One of the major challenges when using DAP against vancomycin-resistant enterococci is the emergence of resistance, which is mediated by the cell-envelope stress system LiaFSR." Keywords: Houston; State:Texas; United States; North and Central America; Antibiotics; Antiinfectives; Biochemicals; Biochemistry; Chemicals; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Enterococcaceae; Enterococcus; Enterococcus faecium; Enzymes and Coenzymes; Gram-Positive Bacteria; Health and Medicine; Lactobacillales; Lipopeptides; Peptides; Pharmaceuticals; Transferases EN Houston State:Texas United States North and Central America Antibiotics Antiinfectives Biochemicals Biochemistry Chemicals Cyclic Peptides Daptomycin Therapy Drugs and Therapies Enterococcaceae Enterococcus Enterococcus faecium Enzymes and Coenzymes Gram-Positive Bacteria Health and Medicine Lactobacillales Lipopeptides Peptides Pharmaceuticals Transferases 356 356 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on Gram-Positive Bacteria - Enterococcus faecium are discussed in a new report. [Extracted from the article]

Keywords: Actinomycetales; Antibiotics; Antiinfectives; Biotechnology; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Enzymes and Coenzymes; Gene Editing; Genetics; Genome Editing; Gram-Positive Bacteria; Gram-Positive Endospore-Forming Rods; Health and Medicine; Lipopeptides; Mutagenesis; Peptides; Pharmaceuticals; Streptomyces; Streptomycetaceae; Synthetase EN Actinomycetales Antibiotics Antiinfectives Biotechnology Cyclic Peptides Daptomycin Therapy Drugs and Therapies Enzymes and Coenzymes Gene Editing Genetics Genome Editing Gram-Positive Bacteria Gram-Positive Endospore-Forming Rods Health and Medicine Lipopeptides Mutagenesis Peptides Pharmaceuticals Streptomyces Streptomycetaceae Synthetase 1598 1598 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on gene editing is the subject of a new report. The news correspondents obtained a quote from the research from Zhejiang University: "Traditional rational network refactoring is highly dependent on the comprehensive understanding of regulatory mechanisms and multiple manipulations of genome editing. Actinomycetales, Antibiotics, Antiinfectives, Biotechnology, Cyclic Peptides, Daptomycin Therapy, Drugs and Therapies, Enzymes and Coenzymes, Gene Editing, Genetics, Genome Editing, Gram-Positive Bacteria, Gram-Positive Endospore-Forming Rods, Health and Medicine, Lipopeptides, Mutagenesis, Peptides, Pharmaceuticals, Streptomyces, Streptomycetaceae, Synthetase. [Extracted from the article]

Keywords for this news article include: Orebro, Sweden, Europe, Antimicrobials, Drugs and Therapies, Health and Medicine, Lipopeptides, Peptides and Proteins, Pharmaceuticals, University of Orebro. Keywords: Orebro; Sweden; Europe; Antimicrobials; Drugs and Therapies; Health and Medicine; Lipopeptides; Peptides and Proteins; Pharmaceuticals EN Orebro Sweden Europe Antimicrobials Drugs and Therapies Health and Medicine Lipopeptides Peptides and Proteins Pharmaceuticals 2059 2059 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies - Antimicrobials. Orebro, Sweden, Europe, Antimicrobials, Drugs and Therapies, Health and Medicine, Lipopeptides, Peptides and Proteins, Pharmaceuticals. [Extracted from the article]

According to the news editors, the research concluded: "The use of daptomycin lock therapy could be considered in children with CoNS catheter infection, especially when other antibiotic lock therapy had failed." Keywords: Antibacterials; Antibiotics; Antiinfectives; Antimicrobials; Bacteremia; Bacterial Infections and Mycoses; Cyclic Peptides; Daptomycin Therapy; Drugs and Therapies; Glycopeptide Antibiotics; Glycopeptides Therapy; Health and Medicine; Hospitals; Lipopeptides; Pediatrics; Peptides; Pharmaceuticals; Sepsis; Vancomycin Therapy EN Antibacterials Antibiotics Antiinfectives Antimicrobials Bacteremia Bacterial Infections and Mycoses Cyclic Peptides Daptomycin Therapy Drugs and Therapies Glycopeptide Antibiotics Glycopeptides Therapy Health and Medicine Hospitals Lipopeptides Pediatrics Peptides Pharmaceuticals Sepsis Vancomycin Therapy 843 843 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on bacteremia. [Extracted from the article]

P17 lipopeptide could be used as an excellent drug carrier and play the combined anticancer effect of P17 and anticancer drugs." The release of Dox from P17 @ Dox in cells was timedependment, and the P17 @ Dox nanomedicine had a good anticancer effect. Keywords: Yantai; People's Republic of China; Asia; Anticancer Agents; Cancer; Cancer Therapy; Drugs and Therapies; Emerging Technologies; Health and Medicine; Lipopeptides; Nanomedicine; Nanomedicines; Nanotechnology; Oncology; Peptides and Proteins; Protective Agents EN Yantai People's Republic of China Asia Anticancer Agents Cancer Cancer Therapy Drugs and Therapies Emerging Technologies Health and Medicine Lipopeptides Nanomedicine Nanomedicines Nanotechnology Oncology Peptides and Proteins Protective Agents 446 446 1 06/19/23 20230623 NES 230623 2023 JUN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Nanotechnology - Nanomedicine. [Extracted from the article]

Amides, Antibiotics, Antiinfectives, Bacillales, Beta-Lactam Antibiotics, Beta-Lactam Resistance, Ceftobiprole Therapy, Cyclic Peptides, Dalbavancin Therapy, Dalvance Therapy, Daptomycin Therapy, Drug Resistance, Drugs and Therapies, Endospore-Forming Bacteria, Glycopeptide Antibiotics, Glycopeptides Therapy, Gram-Positive Bacteria, Gram-Positive Cocci, Gram-Positive Endospore-Forming Rods, Health and Medicine, Linezolid Therapy, Lipopeptides, Methicillin Resistance, Methicillin Therapy, Organic Chemicals, Penicillin Resistance, Penicillins, Peptides, Pharmaceuticals, Staphylococcaceae, Staphylococcus, Staphylococcus aureus, Vancomycin Therapy Keywords for this news article include: University Hospital Heraklion, Crete, Greece, Europe, Antiinfectives, Pharmaceuticals, Amides, Bacillales, Lipopeptides, Cyclic Peptides, Drug Resistance, Dalvance Therapy, Linezolid Therapy, Organic Chemicals, Staphylococcaceae, Daptomycin Therapy, Vancomycin Therapy, Dalbavancin Therapy, Drugs and Therapies, Gram-Positive Cocci, Health and Medicine, Methicillin Therapy. [Extracted from the article]