1. Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review.
- Author
-
Strina, Agostino, Barreto, Mauricio L., Cooper, Philip J., and Rodrigues, Laura C.
- Subjects
ASTHMA risk factors ,BREASTFEEDING ,CONFIDENCE intervals ,MEDICINE ,OBESITY ,RESEARCH funding ,RESPIRATORY infections ,RESPIRATORY organ sounds ,SYSTEMATIC reviews ,EVIDENCE-based medicine ,PROFESSIONAL practice ,HOME environment ,SOCIAL context ,FAMILY history (Medicine) ,ODDS ratio ,ADOLESCENCE ,CHILDREN ,HISTORY - Abstract
Background The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings. Objective To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents. Methods A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE. Results Studies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with nonatopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects. Conclusions More research using standardized methodology is needed on the causes of non-atopic asthma. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF