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Nagashima-type palmoplantar keratosis (PPK) is characterised by transgressive PPK with an autosomal recessive trait [1]. We describe a case of melanoma in a patient with Nagashima-type PPK.A 63-year-old Japanese woman presented with erythematous hyperkeratotic lesions on her palms and soles that had persisted since infancy. The lesions extended to the dorsal surfaces of the hands and feet and the Achilles tendon area, showing a whitish appearance after bathing. There was no family member with similar [...]

Nagashima-type palmoplantar keratosis (NPPK, MIM 615598) is an autosomal recessive disorder, first described by Nagashima [1-4]. It is characterized by diffuse mild palmoplantar hyperkeratosis that extends onto the dorsum of hands and feet and the Achilles tendon areas. Elbows and knees are also involved and palmoplantar hyperhidrosis is common. Recently, causative loss-of-function mutations in the SERPINB7 gene were identified [4-6]. Here we report a case of a patient with compound heterozygous [...]

Nagashima-type palmoplantar keratosis (PPK) is characterized by transgressive and non-progressive PPK with an autosomal recessive trait. Nagashima-type PPK was first described in a report from Japan in 1977 [1]. Although more than 20 cases of Nagashima-type PPK have been reported since then [2], no studies have been conducted in regard to the complications of this disorder. In this report, we present a case of malignant melanoma (MM) arising in the skin lesions of Nagashima-type PPK.A 64-year-old [...]

ejd.2012.1676 Auteur(s) : Yumi Nonomura, Atsushi Otsuka, Yoshiki Miyachi, Kenji Kabashima kaba@kuhp.kyoto-u.ac.jp Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara Sakyo, Kyoto 606-8507, Japan Nagashima-type palmoplantar keratosis (PPK), which was first described in 1977 [1], is characterized by transgressive and non-progressive PPK as an autosomal recessive trait. About 20 cases, including members of several families, have been reported in the Japanese literature [...]

Auteur(s) : Satoshi Nakamizo, Kenzo Takahashi, Yoshiki Miyachi, Kenji Kabashima Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, 606-8507, Japan “Nagashima-type” keratosis palmoplantaris is characterized by transgressive and non-progressive palmoplantar keratosis (PPK), which was first described in a 1977 report from Japan [1]. Since then, about 20 cases have been reported in the Japanese literature [2] until recently, [...]