1. Radiolabeled bioactive benzoheterocycles for imaging β-amyloid plaques in Alzheimer's disease.
- Author
-
Yang, Yanping and Cui, Mengchao
- Subjects
- *
ALZHEIMER'S disease diagnosis , *RADIOLABELING , *BIOACTIVE compounds , *HETEROCYCLIC compounds , *AMYLOID plaque , *NEURODEGENERATION , *POSITRON emission tomography - Abstract
Alzheimer's disease (AD) is a debilitating neurodegenerative dementia that involves substantial neuronal loss. Extracellular deposition of neurotoxic β -amyloid (A β ) plaques in the brain has been recognized as the central histological characteristic of AD. In the past decade, precise detection of the A β plaques at preclinical AD with positron emission tomography (PET) or single photon emission computed tomography (SPECT) has achieved continued development. A big category of A β imaging agents was benzoheterocycles which derived from Thioflavin-T (ThT), a traditional amyloid binding dye. This review summarizes the past and current status of radioactive benzoheterocycles designed to selectively bind to A β plaques. Separate sections discuss the chemical synthesis, in vitro and in vivo investigations of radiolabeled benzothiazole, benzoxazole, benzofuran, benzothiophene, indole, imidazopyridine and quinoxaline analogs to act as PET/SPECT candidates for imaging A β plaques. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF