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Your search keyword '"Joshi, Shrinivas D"' showing total 1 results
Start Over Author "Joshi, Shrinivas D" Topic antimicrobial activity Journal european journal of medicinal chemistry

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1 results on '"Joshi, Shrinivas D"'

1. Synthesis, biological evaluation and docking studies of 4-aryloxymethyl coumarins derived from substructures and degradation products of vancomycin.

Author

Revankar, Hrishikesh M., Kulkarni, Manohar V., Joshi, Shrinivas D., and More, Uttam A.

Subjects
*MOLECULAR docking, *HETEROCYCLIC compounds synthesis, *COUMARINS, *CHEMICAL decomposition, *VANCOMYCIN, *ASPERGILLUS niger, *CANDIDA albicans, *CHEMICAL synthesis
Abstract

Abstract: Two series of 4-aryloxymethyl coumarins derived from the reaction of 4-bromomethyl coumarins with ethyl gallate and ethyl ester of N-Benzoyl tyrosine have been synthesized. Gallate ethers 3a–3g and tyrosine derivatives 4e–4j were most effective against Entercoccus faecalis. They were also found to be effective against Aspergillus niger and Candida albicans. Comparative docking studies with novobiocin have indicated better binding ability and higher ‘C’ score values than novobiocin. [Copyright &y& Elsevier]

Published
2013
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