1. A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale
- Author
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Jan Hubeňák, Stefan Kaiser, Armida Mucci, W. Wolfgang Fleischhacker, Gabriele Sachs, Andreas Erfurth, Sonia Dollfus, Jan Libiger, Ingrid Melle, Stephen F. Austin, Paweł Wójciak, Karoline Gütter, István Bitter, Birte Glenthøj, Alp Üçok, A. Vignapiano, Mette Ødegaard Nielsen, Oleg Papsuev, Alex Hofer, Camille Delouche, Igor Gladyshev, Giulia Maria Giordano, Silvana Galderisi, Janusz K. Rybakowski, Mucci, A., Vignapiano, A., Bitter, I., Austin, S. F., Delouche, C., Dollfus, S., Erfurth, A., Fleischhacker, W. W., Giordano, G. M., Gladyshev, I., Glenthoj, B., Gutter, K., Hofer, A., Hubenak, J., Kaiser, S., Libiger, J., Melle, I., Nielsen, M. O., Papsuev, O., Rybakowski, J. K., Sachs, G., Ucok, A., Wojciak, P., and Galderisi, S.
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Adult ,Male ,BNSS ,Negative symptom ,Context (language use) ,PANSS-negative subscale ,03 medical and health sciences ,ddc:616.89 ,0302 clinical medicine ,Extrapyramidal symptoms ,medicine ,Humans ,Pharmacology (medical) ,Avolition ,Biological Psychiatry ,Depression (differential diagnoses) ,Pharmacology ,Psychiatric Status Rating Scales ,Positive and Negative Syndrome Scale ,business.industry ,Discriminant validity ,Functional outcome ,medicine.disease ,030227 psychiatry ,Europe ,Psychiatry and Mental health ,Neurology ,Schizophrenia ,Female ,Schizophrenic Psychology ,Neurology (clinical) ,Negative symptoms ,medicine.symptom ,business ,Psychosocial ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms. (C) 2019 The Author(s). Published by Elsevier B.V.
- Published
- 2019