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2. Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome.

Author

Oka, Shin-ichi, Liu, Wenrui, Masutani, Hiroshi, Hirata, Hiromi, Shinkai, Yoichi, Yamada, Shu-ichi, Yoshida, Toru, Nakamura, Hajime, and Yodoi, Junji

Subjects
*FATTY acids, *CARRIER proteins, *GLUCOSE, *CARBOXYLIC acids, *BIOLOGICAL transport, *PROTEIN binding, *MONOSACCHARIDES, *SUCROSE
Abstract

The article discusses impaired fatty acid utilization in thiredoxin binding protein-2 (TBP-2)-deficient mice. TBP-2-/- mice are predisposed to death with severe bleeding during fasting. Glucose supplementation corrected the fatal anomaly in TBP-2-/- mice, while fatty acids were unable to do so.

Published
2006
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