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1. miR-10a controls glioma migration and invasion through regulating epithelial–mesenchymal transition via EphA8.

Author

Yan, Yan, Wang, Qin, Yan, Xiao-Ling, Zhang, Yi, Li, Wei, Tang, Fan, Li, Xu, and Yang, Ping

Subjects
*MICRORNA, *GLIOMAS, *TUMOR growth, *GENE expression, *CANCER cells, *CANCER invasiveness, *EPITHELIAL cells
Abstract

MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 ( EphA8 ). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced by miR-10a. We further demonstrate that miR-10a and EphA8 regulate epithelial–mesenchymal transition (EMT) to affect cell migration and invasion. Collectively, we unveil a branch of the miR-10a/ EphA8 pathway that regulates the progression of glioma. [ABSTRACT FROM AUTHOR]

Published
2015
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