1. Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
- Author
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Shi, Yan-Hong, Zhu, Shu, Ge, Yue-Wei, He, Yu-Min, Kazuma, Kohei, Wang, Zhengtao, Yoshimatsu, Kayo, and Komatsu, Katsuko
- Subjects
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ALLERGY prevention , *ALTERNATIVE medicine , *ANIMAL experimentation , *BIOLOGICAL assay , *BIOLOGICAL models , *PHYSICAL & theoretical chemistry , *IMMUNOGLOBULINS , *MASS spectrometry , *MEDICINAL plants , *RATS , *PLANT roots , *TERPENES , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies - Abstract
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol ( 1 ), 4′-hydroxypaeoniflorigenone ( 2 ) and 4- epi -albiflorin ( 3 ), together with 13 known ones ( 4–16 ). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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