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• 2-Methyl-5-phenylpentanol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Furfural; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Hexyl butyrate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Octyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Octyl formate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 4-Isopropyl-1-methylcyclohexene; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Allyl α-ionone; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Hexyl formate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 7-Isopropyl-1,4-dimethylazulene; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Lauryl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 3-Methyl-5-phenylpentanol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• p -Mentha-1,8-dien-7-ol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Octyl butyrate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Nonyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 1-Oxaspiro[4.5]decan-2-one, 8-methyl-; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 1-Oxaspiro[4.5]decan-2-one, 8-ethyl-, trans -; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 2,2-Dimethyl-3-phenylpropanol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 5-(cis -3-Hexenyl)dihydro-5-methyl-2(3H)furanone; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 3-(Methylthio)hexyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• o -Phenyl anisole; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Geranyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Geranyl linalool; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Ionone (mixed isomers); a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Hexyl propionate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Ethyl salicylate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Isopropyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Decyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• α-Butylcinnamaldehyde; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Isopropyl butyrate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Veratraldehyde; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Musk ketone; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 4-Phenyl-3-buten-2-ol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 2-Hydroxybenzoic acid; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 5-Methylfurfural; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

The existing information supports the use of this material as described in this safety assessment. 2-Methyl-4-phenylbutyraldehyde was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog β-methyl-benzenepentanal (CAS # 55,066-49-4) show that 2-methyl-4-phenylbutyraldehyde is not expected to be genotoxic and provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity endpoint. Data on read-across analog phenylacetaldehyde (CAS # 122-78-1) provide a calculated MOE >100 for the reproductive toxicity endpoint. Data show that there are no safety concerns for 2-methyl-4-phenylbutyraldehyde for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 2-methyl-4-phenylbutyraldehyde is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 2-methyl-4-phenylbutyraldehyde is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 2-methyl-4-phenylbutyraldehyde was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1. • 2-Methyl-4-phenylbutyraldehyde; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 2-Methyl-4-phenylpentanol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 3,4,5,6,6-Pentamethylheptan-2-ol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Hexyl acetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• N-Ethyl-N-(3-methylphenyl)propionamide; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• cis -3-Hexenal; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Lavandin abrialis; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Pinus nigra oil; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• β-Methylphenethyl alcohol; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 3-Hexene, 1-[(2-methyl-2-propenyl)oxy]- (3Z)-; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 1, 3- Cyclohexadiene- 1- carboxylic acid, 4, 6, 6- trimethyl-, ethyl ester; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• 2(4H)-Benzofuranone, 5,6-dihydro-3,6-dimethyl-; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Allyl cinnamate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Rotundone; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Propanoic acid, 2-methyl-, cyclohexyl ester; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]

• Cyclohexyl phenylacetate; a safety assessment based on RIFM's criteria. • A safety assessment based on 7 human health endpoints plus environmental. • All endpoints were cleared using target data, read-across, and/or TTC. [ABSTRACT FROM AUTHOR]