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3 results on '"Sungchan Cho"'

2. Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production

Author

Sung Key Jang, Tae-Don Kim, Kyong-Tai Kim, Kyung-Chul Woo, Sungchan Cho, and Dae-Cheong Ha

Subjects
medicine.medical_specialty, Heterogeneous nuclear ribonucleoprotein, AANAT, Molecular Sequence Data, Biology, Arylalkylamine N-Acetyltransferase, Models, Biological, Pineal Gland, Heterogeneous-Nuclear Ribonucleoproteins, Pinealocyte, Melatonin, Pineal gland, Internal medicine, Translational regulation, Genetics, medicine, Animals, Humans, RNA, Messenger, Circadian rhythm, Sheep, Base Sequence, Models, Genetic, General Neuroscience, General Medicine, Molecular biology, Circadian Rhythm, Rats, Cell biology, Internal ribosome entry site, Endocrinology, medicine.anatomical_structure, Protein Biosynthesis, Arylalkylamine, 5' Untranslated Regions, Research Paper, Developmental Biology, medicine.drug
Abstract

The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its species-specific mRNA profiles. Here we show that the circadian timing of AANAT protein expression is regulated by rhythmic translation of AANAT mRNA. This rhythmic control is mediated by both a highly conserved IRES (internal ribosome entry site) element within the AANAT 5′ untranslated region and its partner hnRNP Q (heterogeneous nuclear ribonucleoprotein Q) with a peak in the middle of the night. Consistent with the enhancing role of hnRNP Q in AANAT IRES activities, knockdown of the hnRNP Q level elicited a dramatic decrease of peak amplitude in the AANAT protein profile parallel to reduced melatonin production in pinealocytes. This translational regulation of AANAT mRNA provides a novel aspect for achieving the circadian rhythmicity of vertebrate melatonin.

Published
2007

3. Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production.

Author

Tae-Don Kim, Kyung-Chul Woo, Sungchan Cho, Dae-Cheong Ha, Sung Key Jang, and Kyong-Tai Kim

Subjects
*SEROTONIN, *MELATONIN, *MESSENGER RNA, *NUCLEOPROTEINS, *NEUROTRANSMITTERS
Abstract

The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its species-specific mRNA profiles. Here we show that the circadian timing of AANAT protein expression is regulated by rhythmic translation of AANAT mRNA. This rhythmic control is mediated by both a highly conserved IRES (internal ribosome entry site) element within the AANAT 5' untranslated region and its partner hnRNP Q (heterogeneous nuclear ribonucleoprotein Q) with a peak in the middle of the night. Consistent with the enhancing role of hnRNP Q in AANAT IRES activities, knockdown of the hnRNP Q level elicited a dramatic decrease of peak amplitude in the AANAT protein profile parallel to reduced melatonin production in pinealocytes. This translational regulation of AANAT mRNA provides a novel aspect for achieving the circadian rhythmicity of vertebrate melatonin. [ABSTRACT FROM AUTHOR]

Published
2007

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