1. Palladacycle-catalyzed phosphonation of aryl halides in neat water.
- Author
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Xu, Kai, Yang, Fan, Zhang, Guodong, and Wu, Yangjie
- Subjects
PALLADACYCLES ,PALLADIUM catalysts ,ARYL halides ,ORGANIC synthesis ,PHOSPHONATES ,ARYLATION ,CHEMICAL bonds ,ISOPROPYL alcohol - Abstract
An efficient and generally applicable protocol for the palladacycle-catalyzed arylation of diisopropyl H-phosphonate in water was developed. The remarkable features of this C–P bond-forming reaction include wide substrate scope including the inactive electron-rich and electron-neutral aryl chlorides, the weak inorganic base KF instead of strong bases such as KO
t Bu or NaOt Bu for the activation of C–Cl bond, and the addition of isopropanol to avoid the decomposition of diisopropyl H-phosphonate. [ABSTRACT FROM AUTHOR]- Published
- 2013
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