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1. Thyroid volume is progressively reduced as a sequela of neck irradiation for childhood Hodgkin's disease.

Author

Bossi G, Larizza D, Sommaruga G, Corbella F, Klersy C, and Aricò M

Subjects
Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Atrophy, Child, Child, Preschool, Combined Modality Therapy, Female, Hodgkin Disease drug therapy, Humans, Hypothyroidism etiology, Infant, Male, Neck radiation effects, Thyroid Function Tests, Thyroid Gland radiation effects, Hodgkin Disease radiotherapy, Radiation Injuries pathology, Radiotherapy adverse effects, Thyroid Gland pathology
Abstract

Thyroid volume reduction was observed, among 25 subjects off-therapy after Hodgkin's disease. The volume reduction was related to dose (p = 0.014) and time from radiotherapy (p = 0.01). The correlation was very specific since all patients with reduced volume had hypothyroidism, but not very sensitive since 25% of subjects with thyroid dysfunction had normal gland volume.

Published
1998

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