Search

Brazilian researchers have discovered a potential target for novel therapeutic strategies to combat fungal infections caused by Aspergillus fumigatus. The researchers found that silencing a specific gene attenuated the virulence of the fungus, making it less likely to cause severe lung infections. Resistance to existing antifungals is common, and the available therapies can have adverse side effects. The researchers are now searching for a molecule that inactivates a protein called sirtuin E, which could serve as a basis for a drug that makes the fungus more sensitive to existing medications. [Extracted from the article]

A recent report from the Medical College of Wisconsin discusses the role of sirtuins, which are NAD+-dependent protein deacylases and metabolic regulators. Sirtuins have been associated with both protective and detrimental cellular roles, depending on their activity levels. The report focuses on the current trends in sirtuin activator and inhibitor development, highlighting the selectivity, potency, and cellular activity of these compounds. The research provides recommendations for the best-in-class sirtuin activators and inhibitors for practical research and therapeutic development. [Extracted from the article]

Scientists at the Boyce Thompson Institute and Cornell University have made a significant advancement in biochemistry by uncovering new insights into a family of metabolites called acylspermidines. These metabolites have an unexpected connection to sirtuins, an enzyme family that regulates essential functions in living organisms. Sirtuins have been linked to age-related diseases, making them a promising target for therapeutic interventions. The researchers discovered acylspermidines through comparative metabolomics and found that they are present in both simple organisms and mammals, including humans. Further research will explore the mechanisms and pharmacological aspects of these findings. [Extracted from the article]

Keywords for this news article include: Kerman University of Medical Sciences, Kerman, Iran, Asia, Sirtuins, Amidohydrolases, Endocrine Research, Health and Medicine, Glycosyltransferases, Enzymes and Coenzymes, ADP Ribose Transferases, Group III Histone Deacetylases, Intracellular Signaling Peptides and Proteins. Keywords: ADP Ribose Transferases; Amidohydrolases; Endocrine Research; Enzymes and Coenzymes; Glycosyltransferases; Group III Histone Deacetylases; Health and Medicine; Intracellular Signaling Peptides and Proteins; Sirtuins EN ADP Ribose Transferases Amidohydrolases Endocrine Research Enzymes and Coenzymes Glycosyltransferases Group III Histone Deacetylases Health and Medicine Intracellular Signaling Peptides and Proteins Sirtuins 2947 2947 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New study results on sirtuins have been published. ADP Ribose Transferases, Amidohydrolases, Endocrine Research, Enzymes and Coenzymes, Glycosyltransferases, Group III Histone Deacetylases, Health and Medicine, Intracellular Signaling Peptides and Proteins, Sirtuins. [Extracted from the article]

ADP Ribose Transferases, Connective Tissue Cells, Enzymes and Coenzymes, Fibroblasts, Glycosyltransferases, Group III Histone Deacetylases, Intracellular Signaling Peptides and Proteins, Sirtuins, Amidohydrolases Keywords: ADP Ribose Transferases; Amidohydrolases; Connective Tissue Cells; Enzymes and Coenzymes; Fibroblasts; Glycosyltransferases; Group III Histone Deacetylases; Intracellular Signaling Peptides and Proteins; Sirtuins EN ADP Ribose Transferases Amidohydrolases Connective Tissue Cells Enzymes and Coenzymes Fibroblasts Glycosyltransferases Group III Histone Deacetylases Intracellular Signaling Peptides and Proteins Sirtuins 5098 5098 1 03/27/23 20230331 NES 230331 2023 MAR 31 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New study results on sirtuins have been published. Thus, in this review, we examine the relationship between sirtuin signaling and dermal fibroblasts to understand how this family of proteins may modulate skin conditions ranging from the wound healing process to photocarcinogenesis associated with fibroblast senescence. [Extracted from the article]

Keywords: ADP Ribose Transferases; Amidohydrolases; Arthritis; Autoimmune Diseases and Conditions; Enzymes and Coenzymes; Glycosyltransferases; Group III Histone Deacetylases; Health and Medicine; Intracellular Signaling Peptides and Proteins; Joint Diseases and Conditions; Musculoskeletal Diseases and Conditions; Rheumatoid Arthritis; Sirtuins EN ADP Ribose Transferases Amidohydrolases Arthritis Autoimmune Diseases and Conditions Enzymes and Coenzymes Glycosyltransferases Group III Histone Deacetylases Health and Medicine Intracellular Signaling Peptides and Proteins Joint Diseases and Conditions Musculoskeletal Diseases and Conditions Rheumatoid Arthritis Sirtuins 2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on rheumatoid arthritis is now available. According to news reporting out of Szczecin, Poland, by NewsRx editors, research stated, "Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease leading to joint destruction.". [Extracted from the article]