1. Procedural sedation during transradial coronary angiography to prevent spasm.
- Author
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Astarcioglu MA, Sen T, Kilit C, Durmus HI, Gozubuyuk G, Agus HZ, Kalcik M, Karakoyun S, Yesin M, Dogan A, and Ozkan M
- Subjects
- Catheterization, Peripheral methods, Coronary Angiography methods, Coronary Artery Disease therapy, Humans, Hypnotics and Sedatives administration & dosage, Male, Midazolam administration & dosage, Middle Aged, Radiographic Image Enhancement methods, Reproducibility of Results, Sensitivity and Specificity, Spasm etiology, Treatment Outcome, Catheterization, Peripheral adverse effects, Conscious Sedation methods, Coronary Angiography adverse effects, Coronary Artery Disease diagnostic imaging, Radial Artery drug effects, Spasm prevention & control
- Abstract
Aim: Radial artery spasm is common during transradial procedures and is the most common cause of procedural failure. The objectives of this study were to assess whether the routine administration of sedation at the beginning of transradial coronary angiography with the use of hydrophilic-coated and smaller sheaths/catheters would reduce the incidence of radial artery spasm., Patients and Methods: Patients undergoing transradial coronary angiography were prospectively randomized to receive midazolam during the procedure or no sedative treatment. The primary endpoint was angiographically confirmed radial artery spasm. Stenosis of the radial artery was measured with a computer-assisted quantification method., Results: In all, 150 patients were randomized into a treatment group and a control group. Spasm occurred in 15 patients of the treatment group (20 %) versus 16 in the control group (21.3 %). There were no differences between the two groups regarding the incidence of spasm and the distribution of spasm severity (p > 0.05). No significant differences were observed between the two groups in terms of 30-day mortality or repeat hospitalization for any cause (p > 0.05)., Conclusion: Routine use of midazolam could not reduce the occurrence of radial artery spasm during transradial coronary angiography.
- Published
- 2016
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