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Start Over Author "Srikumar, Ramakrishnan" Journal infection and immunity
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2. fhuAof Actinobacillus pleuropneumoniaeEncodes a Ferrichrome Receptor but Is Not Regulated by Iron

Author

Mikael, Leonie G., Srikumar, Ramakrishnan, Coulton, James W., and Jacques, Mario

Abstract

ABSTRACTThe swine pathogen Actinobacillus pleuropneumoniaepossesses a 75-kDa outer membrane protein (OMP), FhuA, the receptor for ferrichrome, a hydroxamate-type siderophore. Polyclonal serum to FhuA reacted with OMP preparations from 12 serotypes of A. pleuropneumoniaeunder conditions of iron repletion and restriction. Reverse transcription-PCR confirmed that A. pleuropneumoniae fhuAexpression is not upregulated in response to low iron levels. An A. pleuropneumoniae fhuAdeletion mutant was generated and showed abolishment of ferrichrome uptake.

Published
2003
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