1. Epidermal growth factor receptor and v-Ki-ras2 Kirsten rat sarcoma viral oncogen homologue-specific amino acid substitutions are associated with different histopathological prognostic factors in resected non-small-cell lung cancer
- Author
-
Nicola Santelmo, Michèle Legrain, Mickaël Schaeffer, Pierre-Emmanuel Falcoz, Marie-Pierre Chenard, Stéphane Renaud, Noëlle Weingertner, Michèle Beau-Faller, Gilbert Massard, Joseph Seitlinger, Anne-Claire Voegeli, Jérémie Reeb, and Anne Olland
- Subjects
Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pathology ,Lung Neoplasms ,medicine.disease_cause ,Gastroenterology ,Proto-Oncogene Proteins p21(ras) ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,medicine ,Humans ,Epidermal growth factor receptor ,Lung cancer ,Lymph node ,Carcinogen ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,Mutation ,biology ,business.industry ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,ErbB Receptors ,030104 developmental biology ,medicine.anatomical_structure ,Amino Acid Substitution ,030220 oncology & carcinogenesis ,biology.protein ,Female ,Surgery ,Sarcoma ,KRAS ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES Epidermal growth factor receptor (mEGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogen homologue (mKRAS) mutations are the two main oncogenic drivers in resected non-small-cell lung cancer (NSCLC). We aimed to evaluate the correlation between histopathological prognostic factors and these mutations in resected NSCLC. METHODS We retrospectively reviewed data from 841 patients who underwent a surgical resection with a curative intent for NSCLC between 2007 and 2012. RESULTS KRAS mutations were observed in 255 patients (32%) and mEGFR in 103 patients (12%). A correlation was observed between mKRAS patients and lymph node involvement [Cramer's V: 0.451, P < 0.001, OR: 7.5 (95% CI: 5.3-10.7), P < 0.001]. Otherwise, a correlation was observed between mKRAS and the risk of harbouring 2 N2 stations [Cramer's V: 0.235, P = 0.02, OR: 3.04 (95% CI: 1.5-6.3), P = 0.004]. High lymph node ratio and angioinvasion were also significantly more frequent in mKRAS [Cramer's V: 0.373, P < 0.001, OR: 6.37 (95% CI: 3.9-10.5), P < 0.001; and Cramer's V: 0.269, P < 0.001, OR: 3.25 (95% CI: 2.4-4.4), P < 0.001, respectively]. Skip N2 and microscopic N2 were significantly more frequent in mEGFR [Cramer's V: 0.459, P < 0.001, OR: 18 (95% CI: 5.6-57.8), P < 0.001; and (Cramer's V: 0.45, P < 0.001 OR: 21.14 (95% CI: 9.2-48.3), P < 0.001, respectively]. CONCLUSIONS We observed a correlation between mKRAS and negative histopathological prognostic factors and between mEGFR and positive prognostic factors. One can wonder whether histopathological prognostic factors are only clinical reflections of molecular alterations.
- Published
- 2016