1. The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study
- Author
-
Kamsang Woo, Ping Chook, David S. Celermajer, K H A Lau, Yuehui Yin, Y Leung, D S Guo, C Y T Kwok, An N Wei, P W A Lee, Y J Hu, Xiang Qian Lao, Changqing Lin, and K S Leung
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,Waist ,Epidemiology ,Diastole ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Air Pollution ,Medicine ,Aerodynamic diameter ,Humans ,030212 general & internal medicine ,Aged ,business.industry ,Cholesterol ,General Medicine ,Middle Aged ,Atherosclerosis ,Confidence interval ,Blood pressure ,chemistry ,Cardiology ,Yangtze river ,Hong Kong ,Particulate Matter ,business ,Body mass index - Abstract
Background Air pollution has been associated with an increase in cardiovascular diseases incidence. To evaluate whether air pollution can accelerate atherogenic processes, we assessed the effects of air pollution on important surrogate markers of atherosclerosis [brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT)]. Methods A total of 1656 Han Chinese (mean age 46.0 + 11.2 years; male 47%) in Hong Kong, Macau, Pun Yu, Yu County and the 3-Gorges Territories (Yangtze River) were studied between 1996 and 2007 [Chinese Atherosclerosis in the Aged and Young Project (the CATHAY Study)]. Cardiovascular risk profiles were evaluated. Particulate matter with an aerodynamic diameter Results Health parameters [age, gender, body mass index, waist : hip ratio (WHR) and glucose)] were similar in lowest and highest PM2.5 exposure tertiles, systolic and diastolic blood pressures and triglycerides were higher (P Conclusions Air pollution is strongly associated with markers of early atherosclerosis, suggesting a potential target for preventive intervention.
- Published
- 2020