1. Successful treatment of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia
- Author
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Hideyuki Kuwabara, Yuki Nakajima, Rika Ohshima, Yukako Hattori, Rika Sakai, Naoto Tomita, Yoshiaki Ishigatsubo, Masakazu Kitagawa, and Shin Fujisawa
- Subjects
Adult ,Vincristine ,medicine.medical_specialty ,Pediatrics ,Cyclophosphamide ,medicine.medical_treatment ,Prednisolone ,Philadelphia chromosome ,Pregnancy ,hemic and lymphatic diseases ,Remission Induction Therapy ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Philadelphia Chromosome ,Chemotherapy ,Acute leukemia ,business.industry ,Daunorubicin ,Remission Induction ,Imatinib ,Hematology ,Induction Chemotherapy ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Surgery ,Female ,business ,Live Birth ,Pregnancy Complications, Neoplastic ,medicine.drug - Abstract
The management of acute leukemia during pregnancy is challenging. Delays in treatment for acute leukemia can adversely affect maternal prognosis, but chemotherapy during pregnancy may induce severe adverse effects on the fetus. Here, we report a case of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+)ALL) who underwent remission induction therapy and successfully delivered a live infant after chemotherapy. The case is a 36-year-old woman diagnosed with Ph(+)ALL in the 27th week of pregnancy. She underwent remission induction therapy including daunorubicin, vincristine, cyclophosphamide, and prednisolone. Imatinib was not used in the induction therapy. She delivered the infant after one course of chemotherapy. The infant and the patient are both alive now, without any major complications.
- Published
- 2012