1. Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus
- Author
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Joany Sarmiento Gutierrez, Fernando de la Cruz Lopez, Roberto Navarro Quiroz, Aniyensy Sarai Flores-Aguilar, Karime Macias-Ochoa, Yesit Bello Lemus, Carlos G. Musso, Esperanza Diaz Arroyo, Elkin Navarro Quiroz, Mostapha Ahmad, Gustavo Aroca Martínez, Jainy Meza, Francisco Morales-Navarrete, Anderson Díaz Pérez, Valeria Chavez-Estrada, María Fernanda Ayala-Navarro, Lorena Gomez Escorcia, Andres Cadena Bonfanti, and Henry Gonzales Torres
- Subjects
0301 basic medicine ,Glycosylation ,Epigenetic mechanisms ,epigenetic mechanisms ,SUMO protein ,Review ,Biology ,ubiquitination ,Hydroxylation ,Catalysis ,Epigenesis, Genetic ,Inorganic Chemistry ,03 medical and health sciences ,Systemic lupus erythematosus ,0302 clinical medicine ,systemic lupus erythematosus ,Ubiquitin ,Animals ,Humans ,Lupus Erythematosus, Systemic ,Sulfation ,Epigenetics ,Phosphorylation ,Physical and Theoretical Chemistry ,Differential expression ,skin and connective tissue diseases ,Molecular Biology ,Gene ,Spectroscopy ,Organism ,030203 arthritis & rheumatology ,phosphorylation ,Organic Chemistry ,sulfation ,Ubiquitination ,Acetylation ,General Medicine ,Subcellular localization ,SUMOylation ,Computer Science Applications ,030104 developmental biology ,Posttranslational modifications ,biology.protein ,posttranslational modifications ,Protein Processing, Post-Translational ,Neuroscience - Abstract
The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the differential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.
- Published
- 2019
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