1. Longitudinal Changes over 2 Years in Parotid Glands of Patients Treated with Preoperative 30-Gy Irradiation for Oral Cancer
- Author
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Toshinori Hirai, Tomoko Nomura, Yuji Nakaguchi, Masanori Shinohara, Etsushi Tomitaka, Yasuyuki Yamashita, Yushi Araki, Keiko Teshima, Hideki Nakayama, Ryuji Murakami, and Mika Kitajima
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Saliva ,Time Factors ,medicine.medical_treatment ,Xerostomia ,Preoperative care ,stomatognathic system ,Preoperative radiation ,medicine ,Humans ,Parotid Gland ,Radiology, Nuclear Medicine and imaging ,Irradiation ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Cancer ,Organ Size ,Recovery of Function ,General Medicine ,Middle Aged ,medicine.disease ,Neoadjuvant Therapy ,Surgery ,Parotid gland ,Radiation therapy ,stomatognathic diseases ,medicine.anatomical_structure ,Oncology ,Chemotherapy, Adjuvant ,Total dose ,Carcinoma, Squamous Cell ,Female ,Mouth Neoplasms ,Radiotherapy, Adjuvant ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,Follow-Up Studies - Abstract
Objective: To evaluate longitudinal changes in parotid volumes and saliva production over 2 years after 30 Gy irradiation. Methods: We retrospectively evaluated 15 assessable patients treated for advanced oral cancer. Eligibility criteria were a pathologic diagnosis of squamous cell carcinoma, preoperative radiation therapy with a total dose of 30 Gy delivered in 15 fractions, and the availability of longitudinal data of morphological assessments by computed tomography and functional assessments with the Saxon test spanning 2 years after radiation therapy. In the Saxon test, saliva production was measured by weighing a folded sterile gauze pad before and after chewing; the low-normal value is 2 g/2 min. Repeated-measures analysis of variance with Bonferroni adjustment for multiple comparisons was used to determine the longitudinal changes. Results: The normalized ipsilateral parotid volumes 2 weeks and 6-, 12- and 24 months after radiation therapy were found to be 72.5, 63.7, 66.9 and 78.1%, respectively; the normalized contralateral volumes were 69.8, 64.6, 72.2 and 82.0%, respectively. The bilateral parotid volumes were significantly decreased after radiation therapy (P , 0.01). The nadir appeared at 6 months post-radiation therapy and the volumes substantially recuperated 24 months after radiation therapy (P , 0.01). Mean saliva production before radiation therapy was 3.7 g; the longitudinal changes after radiation therapy were 31.3, 38.0, 43.3 and 69.6%, respectively. Substantial recuperation of saliva production was observed 24 months after radiation therapy (P ¼ 0.01). Conclusions: Although parotid volumes and saliva production were decreased after 30 Gy irradiation, we observed the recuperation of morphological and functional changes in the parotid glands 2 years after radiation therapy.
- Published
- 2011