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Your search keyword '"Stavudine -- Physiological aspects"' showing total 7 results
Start Over Descriptor "Stavudine -- Physiological aspects" Journal journal of acquired immune deficiency syndromes (1999)
7 results on '"Stavudine -- Physiological aspects"'

1. Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didnosine

Author

Miro, Oscar, Marinez, Esteban, Giralt, Marta, Vilarroya, Francesc, Casademont, Jordi, Concepcion, Marisa Rodriguez de la, Lopez, Sonia, Gsttsbou, Gloria, Pedrol, Enric, Gatell, Josep M., and Cardellach, Francesc

Subjects
Stavudine -- Physiological aspects, Stavudine -- Chemical properties, Mitochondrial DNA -- Research, Antiviral agents -- Analysis, Antiviral agents -- Physiological aspects, Health
Abstract

The certainty that the homeostatic mechanisms are able to compensate for this mtDNA depletion in patients receiving stavudine plus didnosine(d4T+ ddI), an antiretroviral combination with great in vitro and in vivo capacity to decrease mtDNA is determined. The study concludes that treatment with ddT=ddI is associated with decreased mitochondrial mass and mtDNA content but that cytochrome c oxidase subnit II (COX-II) expression and COX activity remain unaltered.

Published
2004

2. Results of a phase 2 clinical trial at 48 weeks (AI424-007): a dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects

Author

Sanne, Ian, Piliero, Peter, Squires, Kathleen, Thirty, Alexandra, and Schnittman, Steven

Subjects
Clinical trials -- Comparative analysis, Stavudine -- Dosage and administration, Stavudine -- Physiological aspects, Didanosine -- Dosage and administration, Didanosine -- Physiological aspects, Drug therapy -- Analysis, Drug therapy -- Usage, Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Drug therapy, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Antiviral agents -- Dosage and administration, Antiviral agents -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on protease inhibitor atazanavir. The dose levels of this medication have been compared with those of nelfinavir as a monotherapy and in combination with didanosine and stavudine, and the results of this clinical trial carried out to compare safety, tolerability and antiretroviral efficacy of these three doses are reported.

Published
2003

3. Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine or stavudine, each in combination with lamivudine and indinavir

Author

Descamps, Diane, Flandre, Philippe, Joly, Veronique, Meiffredy, Vincent, Peytavin, Gilles, Izopet, Jacques, Tamalet, Catherine, Ai-Feng Zeng, Harel, Marine, Lastere, Stephane, Aboulker, Jean-Pierre, Yeni, Patrick, and Brun-Vezinet, Francoise

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Drug therapy, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Genetic aspects, HIV infection -- Health aspects, Gene mutations -- Physiological aspects, Drug therapy -- Health aspects, Drug therapy -- Analysis, Zidovudine -- Genetic aspects, Zidovudine -- Physiological aspects, Stavudine -- Physiological aspects, Lamivudine -- Physiological aspects, Indinavir -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on zidovudine resistance mutations. The role of these mutations in virologic response to treatment with zidovudine or stavudine in combination with lamivudine and indinavir has been investigated, and the results demonstrate that zidovudine resistance mutations do not preclude a durable response to treatment with a three-drug regimen in the patients.

Published
2002

4. Antiviral activity of enteric-coated didanosine, stavudine, and nelfinavir versus zidovudine plus lamivudine and nelfinavir

Author

Gathe, Joseph, Jr., Badaro, Roberto, Grimwood, Ashraf, Abrams, Lori, Klesczewski, Ken, Cross, Anne, and McLaren, Colin

Subjects
Didanosine -- Physiological aspects, Stavudine -- Physiological aspects, Zidovudine -- Physiological aspects, Lamivudine -- Physiological aspects, Nelfinavir -- Physiological aspects, Enteric-coated tablets -- Physiological aspects, Enteric-coated tablets -- Usage, Epidemiology -- Research, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Health aspects, HIV infection -- Research, HIV infection -- Prevention, Antiviral agents -- Composition, Antiviral agents -- Physiological aspects, Antiviral agents -- Research, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on enteric-coated didanosine beadlets administered once daily. The activity and safety of the capsules which contain these beadlets have been compared with stavudine and nelfinavir, and the results are reported.

Published
2002

5. Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy zidovudine-experienced patients

Author

Shulman, Nancy S., Hughes, Michael D., Winters, Mark A., Shafer, Robert W., Zolopa, Andrew R., Hellmann, Nicholas S., Bates, Michael, Whitcomb, Jeannette M., and Katzenstein, David A.

Subjects
Immunological deficiency syndromes -- Research, Stavudine -- Physiological aspects, Stavudine -- Usage, Virology -- Research, Drug resistance -- Research, Drug resistance -- Health aspects, Drug resistance -- Physiological aspects, Zidovudine -- Usage, Zidovudine -- Physiological aspects, AIDS patients -- Drug therapy, AIDS patients -- Health aspects, AIDS patients -- Care and treatment, Phenotype -- Research, Health
Abstract

Research has been conducted on stavudine. The study of the phenotypic susceptibility level of this drug associated with a diminished virologic response to stavudine therapy has been carried out via phenotyping, performed on the baseline HIV isolates from the patients who received stavudine monotherapy, and the details are reported.

Published
2002

6. Abnormalities of body fat distribution in HIV-infected persons treated with antiretroviral drugs

Author

Bernasconi, Enos, Boubaker, Karim, Junghans, Cornelia, Flepp, Markus, Furrer, Hans-Jakob, Haensel, Alexander, Boggian, Katia, Chave, Jean-Philippe, Opravil, Milos, Weber, Rainer, Rickenbach, Martin, Telenti, Amalio, and Hirschel, Bernard

Subjects
Epidemiology -- Research, HIV infection -- Care and treatment, HIV infection -- Prevention, HIV infection -- Health aspects, HIV patients -- Drug therapy, HIV patients -- Physiological aspects, HIV patients -- Health aspects, Stavudine -- Health aspects, Stavudine -- Physiological aspects, Lipodystrophy -- Health aspects, Lipodystrophy -- Causes of, Health
Abstract

Research has been conducted on the abnormal body fat distribution in HIV-infected persons. Results demonstrate that the prevalence of lipodystrophy is higher among the patients treated with stavudine for a longer period of time.

Published
2002

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