1. Determination of Aromatic Amines Released from Azo Dyes in Paper Packaging by Liquid Chromatography-Tandem Mass Spectrometry
- Author
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Liu Shanshan, Huimin Deng, Yang Fei, Zhonghao Li, Gangling Tang, Fan Ziyan, Zhaoyang Bian, and Wang Ying
- Subjects
Paper ,02 engineering and technology ,Tandem mass spectrometry ,01 natural sciences ,Analytical Chemistry ,Sodium dithionite ,chemistry.chemical_compound ,Tandem Mass Spectrometry ,Liquid chromatography–mass spectrometry ,Environmental Chemistry ,Amines ,Coloring Agents ,Pharmacology ,Chromatography ,010401 analytical chemistry ,Extraction (chemistry) ,Food Packaging ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Food packaging ,Chromatographic separation ,chemistry ,Mass spectrum ,0210 nano-technology ,Citric acid ,Azo Compounds ,Agronomy and Crop Science ,Chromatography, Liquid ,Food Science - Abstract
An LC-tandem MS (LC–MS/MS) method for the determination of 21 kinds of carcinogenic aromatic amines released from azo dyes in food wrappers was used in this research. Sodium dithionite was added to a citric acid buffer medium to reduce and decompose possible azo dyes. The extract was analyzed after liquid–liquid extraction (LLE) and dispersive SPE (d-SPE). The conditions for chromatographic separation, mass spectrum, LLE, and d-SPE were optimized. Under optimal conditions, the LOD was in the range of 0.13–0.35 mg/kg and LOQ in the range of 0.38–1.05 mg/kg, with the addition of standard recoveries of most aromatic amines being ≥80% and RSDs ≤10%. The recoveries for 2,4-diaminotoluene and 2,4-diaminoanisole were significantly lower, being ≤40%. The method was successfully used to analyze 30 practical samples, and the results showed that it is user-friendly, with high sensitivity, rapid control, and low matrix interference.
- Published
- 2016
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