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Start Over Author "Yao, Qiang" Journal journal of asian natural products research Publisher taylor & francis ltd
1 results on '"Yao, Qiang"'

1. Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis.

Author

Zhu, Zhen-Yuan, Yao, Qiang, Liu, Yang, Si, Chuan-Ling, Chen, Jing, Liu, Nian, Lian, Hong-Yu, Ding, Li-Na, and Zhang, Yong-Min

Subjects
*ANIMAL experimentation, *ANTINEOPLASTIC agents, *CELL culture, *GLYCOSIDES, *INFRARED spectroscopy, *MASS spectrometry, *MICE, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *PHARMACEUTICAL chemistry, *RESEARCH funding, *TOXICITY testing, *DESCRIPTIVE statistics
Abstract

Ergosterol 3-O-β-d-glucopyranoside (1a) and ergosterol 3-O-β-d-galactopyranoside (1b) were highly efficiently synthesized and evaluated for their inhibitory activities against two tumor cell lines. The structures of these compounds were extensively confirmed by 1H, 13C NMR, IR, and HRMS. Compounds 1a and 1b exhibited interesting cytotoxic profiles. The antitumor activity of compound 1a was higher than that of 1b. [ABSTRACT FROM AUTHOR]

Published
2012
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