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Start Over Author "Dong, Ze-Xi" Journal journal of asian natural products research
2 results on '"Dong, Ze-Xi"'

2. Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats.

Author

Wu, Wen-Yu, Zhong, Yue, Lu, Yu-Ting, Sun, Ying, Li, Nian-Guang, Shi, Zhi-Hao, Dong, Ze-Xi, Gu, Ting, Xue, Xin, Fang, Fang, Li, He-Min, Tang, Yu-Ping, and Duan, Jin-Ao

Subjects
NEURONS, ANALYSIS of variance, ANIMAL experimentation, ANTIOXIDANTS, BIOCHEMISTRY, CEREBRAL ischemia, FISHER exact test, HISTOLOGICAL techniques, NEUROLOGIC examination, NIMODIPINE, REPERFUSION, RESEARCH funding, SPACE perception, STATISTICS, DATA analysis, REPEATED measures design, DESCRIPTIVE statistics, FLAVONES, WOUNDS & injuries, THERAPEUTICS
Abstract

Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia. [ABSTRACT FROM AUTHOR]

Published
2018
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