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The cytotoxic activity of 36 saponins isolated from roots of Pulsatilla chinensis (Bunge) Regel against the human cancer cell lines (A549, SGC-7901) and the human hepatic cell line (HL-7702) was tested by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay. Saponins 1-14 showed considerable cytotoxic activity, whereas saponins 15-36 showed no significant activity, which suggested that a free carboxylic group located at C-28 of aglycon is essential for their cytotoxic activity. Moreover, the analysis of structure-activity relationships also suggested that the oleanane-type saponins showed better cytotoxic activity than lupane-type saponins, and the length and linkage of glycotic chain attached to C-3 of aglycon displayed an important effect to the potent cytotoxicity. In conclusion, oleanolic acid 3-O-α-L- rhamnopyranosyl-(1 → 2)-[βD-glucopyranosyl-(1 → 4)]-β-L-arabinopyranoside (5) exhibited the most significant cytotoxic activity. [ABSTRACT FROM AUTHOR]

Three new xanthone glycosides, securixanside A ( 1 ), securixanside B ( 2 ), and securixanside C ( 3 ) were isolated from the stems of Securidaca inappendiculata . These compounds were characterized by spectrometric and chemical methods, including FABMS and one- and two-dimensional NMR experiments. [ABSTRACT FROM AUTHOR]

Two new compounds, capilliposide I and capilliposide II, together with a known compound quercetin-3- O -(2,6-di-α- l -rhamnopyranosyl)-β- d -galactopyranoside were isolated from the extracts of the whole herbs of Lysimachia capillipes . Their structures were established through their spectral data and chemical properties. [ABSTRACT FROM AUTHOR]