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Start Over Author "Neleman T" Journal journal of cardiovascular translational research
2 results on '"Neleman T"'

1. The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score

Author

Neleman, T. (Tara), Liu, S. (Shengnan), Tovar Forero, M.N. (Maria N.), Hartman, E.M.J. (Eline), Ligthart, J.M.R. (Jürgen), Witberg, K.Th. (Karen), Cummins, P.A. (Paul), Zijlstra, F. (Felix), Mieghem, N.M. (Nicolas) van, Boersma, H. (Eric), Soest, G. (Gijs) van, Daemen, J. (Joost), Neleman, T. (Tara), Liu, S. (Shengnan), Tovar Forero, M.N. (Maria N.), Hartman, E.M.J. (Eline), Ligthart, J.M.R. (Jürgen), Witberg, K.Th. (Karen), Cummins, P.A. (Paul), Zijlstra, F. (Felix), Mieghem, N.M. (Nicolas) van, Boersma, H. (Eric), Soest, G. (Gijs) van, and Daemen, J. (Joost)

Abstract

Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract: [Figure not available: see fulltext.].

Published
2021
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2. The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score.

Author

Neleman T, Liu S, Tovar Forero MN, Hartman EMJ, Ligthart JMR, Witberg KT, Cummins P, Zijlstra F, Van Mieghem NM, Boersma E, van Soest G, and Daemen J

Subjects
Aged, Automation, Coronary Angiography, Coronary Artery Disease mortality, Coronary Artery Disease therapy, Disease Progression, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Myocardial Revascularization, Predictive Value of Tests, Prognosis, Reproducibility of Results, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Vascular Calcification mortality, Vascular Calcification therapy, Coronary Artery Disease diagnostic imaging, Ultrasonography, Interventional, Vascular Calcification diagnostic imaging
Abstract

Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE)., Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE)., Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05-2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04-1.41, p value = 0.014, respectively)., Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE., (© 2021. The Author(s).)

Published
2021
Full Text
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