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The solubilities of 1,3,5-trifluoro-2,4,6-triiodobenzene (IFB) in 12 pure organic solvents including methanol, ethanol, acetone, toluene, ethyl acetate, 1,4-dioxane, 1,2-dichloroethane, acetonitril...

The solubilities of 2-oxindole in 12 pure organic solvents including acetonitrile (MeCN), dichloromethane, 1,4-dioxane, ethyl acetate (EtOAc), acetone, toluene, methanol, ethanol, 2-propanol, tetra...

The solubilities of 1-naphthaleneacetic acid (NAA) have been measured by the synthetic method in 10 pure organic solvents including methanol, ethanol, 2-propanol, toluene, acetone, acetonitrile, 1,4-dioxane, 1,2-dichloroethane, ethyl acetate, and tetrahydrofuran and binary methanol + water mixtures from (278.25 to 323.55) K under atmospheric pressure. The modified Apelblat equation, λh equation, and Wilson equation were employed to correlate the solubility data. Furthermore, the solubility of NAA in a binary solvent mixture was regressed with a combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) equation and the hybrid equation. According to the calculations based on these equations, the modified Apelblat equation gave the best correlation results with the experimental data in all selected solvents.

The solubilities of 2-isopropylthioxanthone (ITX) in methanol, toluene, ethanol, acetone, ethyl acetate, 1,4-dioxane, and 1,2-dichloroethane were determined at temperatures ranging from (299.15 to 329.85) K under atmospheric pressure by employing the synthetic method. The solid–liquid equilibrium of the mixture was detected by a laser monitoring observation technique and found to increase with an increase in temperature. The experimental solubilities were correlated by the modified Apelblat and λh equations. The modified Apelblat equation fits well with the experimental data with the relative deviation less than 2.86 %. The standard enthalpy and standard entropy of the solution of ITX in different solvents were obtained by van’t Hoff equation together with the modified Apelblat model.

The solid–liquid equilibria of 4-amino-3,6-dichloropyridazine (ADCP) in seven pure organic solvents including methanol, acetone, ethanol, dichloromethane, ethyl acetate, 1,4-dioxane, and tetrahydrofuran were determined with the synthetic method from (278.15 to 333.15) K at atmospheric pressure using a laser monitoring observation technique. The measured solubility data increased with the rise of temperature. These solubility data were correlated with two models: the modified Apelblat and λh (Buchowski) equation. The relative deviation of the modified Apelblat equation was no more than 2.1 %, while that of λh equation was less than 4.5 %. Better correlation results were obtained in most solvents with modified Apelblat equation. Furthermore, using van’t Hoff plot, the calculation was performed to obtain the apparent dissolution enthalpy and entropy of the solution of ADCP in these solvents, based on which the apparent dissolution Gibbs free energy change was deduced.

The solubility of isatin in eight pure solvents including dichloromethane, toluene, acetone, ethyl acetate, 1,4-dioxane, N,N-dimethylformamide, tetrahydrofuran, and acetonitrile were determined from (278.15 to 333.15) K at atmospheric pressure using the synthetic method. The solubility was determined by a laser monitoring observation technique and found to increase with the rise of temperature. The experimental solubilities were correlated by four models including the ideal solution model, the modified Apelblat equation, λh (Buchowski) equation, and Wilson models with the overall average percentage deviations less than 0.52% in all cases. Thermodynamic functions of the solution of isatin in these solvents including apparent standard enthalpy and entropy of solution were obtained by van’t Hoff plot, and the apparent standard Gibbs energy change of solution was also calculated.

The solubility of aceclofenac in six pure solvents from (293.35 to 338.25) K was experimentally measured using a synthetic method. The experimental results indicate obviously that the solubility of aceclofenac in the selected solvents increases with elevated temperature. Furthermore, the experimental solubility data were fitted with modified Apelblat and Wilson models. The results show that the data calculated by the two models agree with the measured data with RMSD values of no more than 2.75 %.

The solubilities of 4-amino-3,6-dichloropyridazine (ADCP) in an ethanol + water mixture were determined from (303.15 to 323.15) K with an interval of 2.5 K at atmospheric pressure using the synthetic method with a laser monitoring observation technique. The solubility of ADCP was found to increase with the rise of temperature and the mole fraction of ethanol. The experimental solubilities were regressed with different models including the modified Apelblat equation, combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R-K) model, and the hybrid model. For the six mixture solvents studied, all of the mean percentage deviations with Apelblat equation are less than 1.7 %.

The solubilities of (S)-indoline-2-carboxylilc acid (SIn2CA) in six pure solvents including water, methanol, ethanol, 1-propanol, 2-propanol, and 1-butanol were determined from (283.15 to 358.15) K at atmospheric pressure using the synthetic method. The solubility was determined by a laser monitoring observation technique and found to increase with the rise of temperature. The experimental solubilities were correlated by the modified Apelblat and λh (Buchowski) equations with the relative deviation less than 3.65% with the modified Apelblat equation and less than 0.023% with the λh equation. Thermodynamic functions of the solution of SIn2CA in different solvents including apparent dissolution enthalpy and entropy were obtained by van’t Hoff equation, and the apparent dissolution Gibbs free energy change was also calculated.

The solubility of 6-chloropyridazin-3-amine in methanol, ethanol, n-butanol, N,N-dimethylformamide, acetone, cyclohexanone, ethyl acetate, and toluene at temperatures ranging from (298.15 to 343.55...