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In this work, nine ternary phase diagrams and three quaternary phase diagrams of different systems at 298.15, 308.15, and 318.15 K were constructed. The ternary solid–liquid phase equilibrium of (u...

The solubility of antofloxacin hydrochloride in deep eutectic solvent (DES) aqueous solutions between choline chloride (ChCl) and p-toluenesulfonic acid (PTS), (ethanol + water), and (ethanol + ace...

The solubilities of 3-nitrobenzonitrile in solvent mixtures of ethyl acetate (1) + methanol (ethanol, n-propanol or isopropyl alcohol) (2) determined over the temperature range from 278.15 to 318.15 K under atmospheric pressure (101.1 kPa) with the isothermal dissolution equilibrium method were reported. They increased with a rise of temperature and mass fraction of ethyl acetate, and the largest solubility value was observed in neat ethyl acetate for all the binary mixtures investigated. The temperature and solvent composition dependence of 3-nitrobenzonitrile solubility was analyzed through the Jouyban–Acree, van’t Hoff–Jouyban–Acree, and Apelblat–Jouyban–Acree models acquiring average relative deviations lower than 1.57% and root-mean-square deviation lower than 11.52 × 10–4 for correlative investigations. In addition, the preferential solvation parameters (δx1,3) of 3-nitrobenzonitrile by ethyl acetate were determined from experimental solubility values by using the inverse Kirkwood–Buff integrals. It...

The thiamphenicol solubility in aqueous cosolvent solutions of ethanol (1), methanol (1), 1,4-dioxane (1), and N,N-dimethylformamide (DMF, 1) was measured via the isothermal dissolution equilibrium method at temperatures ranging from 278.15 to 318.15 K under local pressure (101.1 kPa). At fixed composition of ethanol (methanol, 1,4-dioxane, or DMF) and temperature, the solubility of thiamphenicol was larger in DMF + water mixtures than in the ethanol/methanol/1,4-dioxane mixtures. The local solvent proportions were acquired with the method of inverse Kirkwood–Buff integrals. The absolute value of these preferential solvation parameters were all lower than 1.0 × 10–2 for ethanol (1) + water (2) and 1,4-dioxane (1) + water (2) solutions in water-rich compositions and for methanol (1) + water (2) solutions in whole compositions. In the former two cosolvent mixtures in intermediate compositions and cosolvent-rich regions, thiamphenicol was preferentially solvated by cosolvent. However, for the DMF (1) + water...

Equilibrium solubility of hesperidin in aqueous solutions of ethanol, isopropanol, propylene glycol, and n-propanol was determined by static technique at temperatures ranging from 293.15 to 333.15 K under p = 101.1 kPa. The hesperidin solubility increased monotonously with the increase in mass fraction of ethanol isopropanol, propylene glycol, and n-propanol and temperature. At the same composition of alcohol and temperature, the mole fraction solubility of hesperidin was largest in propylene glycol + water among the four cosolvent mixtures. The solubilities of hesperidin were correlated with Jouyban–Acree model, Apelblat–Jouyban–Acree model, and van’t Hoff–Jouyban–Acree model. The obtained average relative deviations were less than 2.38%.

The solid–liquid equilibrium for thiamphenicol in 13 neat solvents (ethanol, methanol, n-propanol, isopropyl alcohol, n-butanol, acetone, acetonitrile, ethyl acetate, 2-butanone, toluene, water, N,N-dimethylformamide, and 1,4-dioxane) was built with the static method at temperatures T = (278.15 to 318.15) K under pressure of 101.2 kPa, and the thiamphenicol solubilities in the selected solvents were measured by using high-performance liquid chromatography. Generally, the solubility data in mole fraction in the selected solvents ranked as N,N-dimethylformamide > acetone > methanol >1,4-dioxane >2-butanone > ethanol > acetonitrile > ethyl acetate > n-propanol > isopropyl alcohol > water > n-butanol > toluene. The nonrandom two-liquid model, Wilson model, modified Apelblat equation, and λh equation were employed to describe the solubility behavior of thiamphenicol in theses solvents. The maximum values of the RMSD and RAD were 4.08 × 10–4 and 2.02%, respectively, and the correlation results by using the modi...

Solubility of 1-hydroxybenzotriazole in 16 neat solvents including methanol, ethanol, n-propanol, isopropanol, acetone, butanone, isoamyl alcohol, n-hexanol, n-heptanol, isooctyl alcohol, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), ethyl acetate, acetonitrile, 1,4-dioxane, and toluene was measured using the method of isothermal saturation over a temperature range from (278.15 to 313.15) K under atmospheric pressure (101.1 kPa). The mole fraction solubility of 1-hydroxybenzotriazole in the selected solvents increased with an increase of temperature. They followed the order from high to low in studied neat solvents: DMF > DMSO > ethanol > n-propanol > isopropanol > methanol > butanone > acetone >1,4-dioxane > n-heptanol > n-hexanol > isoamyl alcohol > isooctyl alcohol > ethyl acetate > acetonitrile > toluene. The obtained solubility data of 1-hydroxybenzotriazole in the studied solvents were correlated with the λh equation, modified Apelblat equation, and NRTL and Wilson models. The largest valu...

In the present study, the solubility of 4,4′-dihydroxydiphenyl sulfone in mixed solvents of (acetone + methanol), (ethyl acetate + methanol), (acetonitrile + methanol), and (acetone + methanol) were determined experimentally by using the isothermal dissolution equilibrium method within the temperature range from (278.15 to 313.15) K under atmosphere pressure. The solubility increased with increasing temperature in the binary solvent mixtures at constant solvent composition. At constant temperature and solvent composition, the dissolving capacity of 4,4′-dihydroxydiphenyl sulfone in the four binary solvent mixtures ranked as (acetone + ethanol) > (acetone + methanol) > (ethyl acetate + methanol) > (acetonitrile + methanol). The obtained solubility data were correlated by employing the Jouyban–Acree model, modified Apelblat–Jouyban–Acree model, Ma model and Sun model. The four models were proven to give good representation of the experimental solubility data. The largest value of relative average deviations...

The binary solid–liquid phase equilibrium for 4-(methylsulfonyl)benzaldehyde in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, acetonitrile, toluene, and acetic acid were studied experimentally within the temperatures range from (283.15 to 318.15) K under 101.3 kPa by using a static equilibrium method. With the increase in temperature, the solubility of 4-(methylsulfonyl)benzaldehyde in these solvents increased. The solubility values from high to low obeyed the following order in different solvents: acetone > acetonitrile > acetic acid > methanol > ethanol > toluene > 1-butanol > 1-propanol > 2-propanol. The modified Apelblat equation, λh equation, Wilson model, and nonrandom two liquid model were employed to correlate the experimental solubility of 4-(methylsulfonyl)benzaldehyde in the nine solvents. The calculated solubility with the modified Apelblat equation provided better agreement than those with the other three models. Generally, the regressed results by the four thermodynamic mode...