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Start Over Author "Cai, Bin" Topic antineoplastic agents Topic crystal structure Journal journal of chemical research
1 results on '"Cai, Bin"'

1. Synthesis, crystal structure and antitumour activity of 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide.

Author

Xiao-hui Ji, Ling-xia Jin, Cai-bin Zhao, Nan Zheng, Juan Song, Hong-guang Ge, Quan Liu, and Jiu-fu Lu

Subjects
CRYSTAL structure, INDAZOLES, CARBOXAMIDES, X-ray diffraction, ANTINEOPLASTIC agents
Abstract

Compound 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound possesses a distinct inhibitory capacity against proliferation of the A549 and BGC-823 cancer cell lines. [ABSTRACT FROM AUTHOR]

Published
2018
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