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Those comments from Acree on “Effect of β -alanine and the solvent composition on the solubility of solvate of calcium d -pantothenate containing four molecules of methanol and one molecule of water ( d -PC·4MeOH·1H 2 O)” are very valuable and helpful for improving the quality of our paper. Here according to the comments, we make a deep analysis and discussion of our article again. Firstly, we need to make a restatement that S 0 and S actually represent the solubility with no impurity in the solution and the solubility in the solution containing impurity in our article, respectively. Secondly, the experimental solubility was reanalysed by the new Cohen equation suggested by Acree Jr, and the results show that the original Cohen equation could give the better agreement. Finally, the modified Solubility-Polarity equation was adopted to correlate the solubility in terms of the relative dielectric constant. [ABSTRACT FROM AUTHOR]

• Solubility of p -Acetamidobenzoic acid in 12 pure solvents was determined. • Experimental solubility was correlated by the modified Apelblat equation, the λh model and the NRTL model. • The melting point of p -Acetamidobenzoic acid was estimated by the group contribution method. • Sigma profiles and solvation free energy were computed on the basis of COSMO-RS model. The solubility of p -Acetamidobenzoic acid (PAABA) in 12 pure organic solvents was measured using the gravimetric method in the temperature range of 283.15 K to 323.15 K. It was discovered that the solubility curves in different solvents cross each other when the temperature increased. Besides, the modified Apelblat equation, the λh model and the NRTL model were used to fit the measured solubility data of PAABA and the modified Apelblat equation and λh model gave the minor deviation compared with the NRTL model. The underlying mechanism between PAABA and solvent molecules was revealed in light of physical properties, sigma profiles and solvation free energy analysis, based on COSMO-RS model. The results indicated that the solubility of PAABA in most alcohol solvents are related to the value of solvation free energy. These data are helpful to further study the crystallization process of PAABA. [ABSTRACT FROM AUTHOR]

The solubility of boscalid in five pure solvents, including methanol, ethanol, isopropanol, ethyl acetate and n-propyl acetate, and two binary solvent mixtures, including (ethanol + ethyl acetate) and (isopropanol + ethyl acetate), was determined by a gravimetric method with temperatures ranging from (288.15 to 313.15) K. It turns out that the solubility of boscalid increases with the increasing of temperature in all selected solvents. Moreover, it is interesting that the solubility of boscalid in the two binary solvent mixtures performed a maximum effect with the decreasing mole fraction of ethyl acetate at a given temperature. The solubility of boscalid in pure solvents was correlated by the modified Apelblat model and λh model while that in binary solvent mixtures was correlated by the modified Apelblat model, CNIBS/R-K model and Jouyban-Acree model. It is found that all the models could give satisfactory correlation results with less than 3% of all the ARD values. Furthermore, the thermodynamic properties of the mixing processes in all solvents selected were calculated and discussed based on the NRTL model. [ABSTRACT FROM AUTHOR]

The solubility of cefmetazole acid in binary solvent mixtures, (methanol + water), (ethanol + water) and (isopropanol + water), was determined by UV spectroscopic method at temperatures from 278.15 to 303.15 K. The solubility of cefmetazole acid increased with the increase of temperature in all solvents. In (methanol + water) co-solvent mixture, the solubility of cefmetazole acid is maximal in neat methanol. In (ethanol + water) and (isopropanol + water) solvent mixtures, the solubility of cefmetazole acid reaches its maximum when the mole fraction of alcohol is 0.5 and 0.4, respectively. The modified Apelblat equation, the CNIBS/R-K model and the Jouyban–Acree model were applied to correlate the experimental solubility of cefmetazole acid. Moreover, the activity coefficients as well as the thermodynamic properties of mixing were calculated and discussed based on the NRTL model and experimental solubility values. [ABSTRACT FROM AUTHOR]

A laser monitoring dynamic method was used to determine the solubility of 4-aminobutyric acid in five mono-solvents of methanol, formamide, 1,2-propanediol, 1,3-propanediol and water, and (methanol + water) binary solvent mixtures over the temperature ranging from 283.15 K to 323.15 K at atmospheric pressure. It turns out to be that in different mono-solvents, the solubility of 4-aminobutyric acid is temperature dependent and increases with the increasing temperature. While in (methanol + water) binary solvent mixtures, the solubility is positively correlated with temperature and negatively correlated with the mole fraction of methanol. The modified Apelblat equation, λh equation and NRTL_Binary model were employed to correlate the solubility data in five mono-solvents. While in (methanol + water) binary solvent mixtures, the NRTL_Ternary model, CNIBS/R-K model and Jouyban-Acree models were applied. It is found that the correlated results are in good agreement with the experimental results. Furthermore, with the activity coefficients considered, solution mixing thermodynamics were calculated and the dissolution process of 4-aminobutyric acid is also discussed. [ABSTRACT FROM AUTHOR]