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Start Over Author "Shen, Ying" Journal journal of clinical immunology
16 results on '"Shen, Ying"'

1. Correction to: Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency

Author

Kuo, Chen-Yen, primary, Ku, Cheng-Lung, additional, Lim, Hye-Kyung, additional, Hsia, Shao-Hsuan, additional, Lin, Jainn-Jim, additional, Lo, Chia-Chi, additional, Ding, Jing-Ya, additional, Kuo, Rei-Lin, additional, Casanova, Jean-Laurent, additional, Zhang, Shen-Ying, additional, Chang, Luan-Yin, additional, and Lin, Tzou-Yien, additional

Published
2022
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2. Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome

Author

Abolhassani, Hassan, primary, Landegren, Nils, additional, Bastard, Paul, additional, Materna, Marie, additional, Modaresi, Mohammadreza, additional, Du, Likun, additional, Aranda-Guillén, Maribel, additional, Sardh, Fabian, additional, Zuo, Fanglei, additional, Zhang, Peng, additional, Marcotte, Harold, additional, Marr, Nico, additional, Khan, Taushif, additional, Ata, Manar, additional, Al-Ali, Fatima, additional, Pescarmona, Remi, additional, Belot, Alexandre, additional, Béziat, Vivien, additional, Zhang, Qian, additional, Casanova, Jean-Laurent, additional, Kämpe, Olle, additional, Zhang, Shen-Ying, additional, Hammarström, Lennart, additional, and Pan-Hammarström, Qiang, additional

Published
2022
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3. Life-Threatening Enterovirus 71 Encephalitis in Unrelated Children with Autosomal Dominant TLR3 Deficiency

Author

Kuo, Chen-Yen, primary, Ku, Cheng-Lung, additional, Lim, Hye-Kyung, additional, Hsia, Shao-Hsuan, additional, Lin, Jainn-Jim, additional, Lo, Chia-Chi, additional, Ding, Jing-Ya, additional, Kuo, Rei-Lin, additional, Casanova, Jean-Laurent, additional, Zhang, Shen-Ying, additional, Chang, Luan-Yin, additional, and Lin, Tzou-Yien, additional

Published
2022
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4. X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia

Author

Abolhassani, Hassan, primary, Vosughimotlagh, Ahmad, additional, Asano, Takaki, additional, Landegren, Nils, additional, Boisson, Bertrand, additional, Delavari, Samaneh, additional, Bastard, Paul, additional, Aranda-Guillén, Maribel, additional, Wang, Yating, additional, Zuo, Fanglei, additional, Sardh, Fabian, additional, Marcotte, Harold, additional, Du, Likun, additional, Zhang, Shen-Ying, additional, Zhang, Qian, additional, Rezaei, Nima, additional, Kämpe, Olle, additional, Casanova, Jean-Laurent, additional, Hammarström, Lennart, additional, and Pan-Hammarström, Qiang, additional

Published
2021
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5. Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis.

Author

Bolze, Alexandre, Mogensen, Trine H., Zhang, Shen-Ying, Abel, Laurent, Andreakos, Evangelos, Arkin, Lisa M., Borghesi, Alessandro, Brodin, Petter, Hagin, David, Novelli, Giuseppe, Okada, Satoshi, Peter, Jonny, Renia, Laurent, Severe, Karine, Tiberghien, Pierre, Vinh, Donald C., COVID human genetic effort, Aiuti, Alessandro, Al-Muhsen, Saleh, and Al-Mulla, Fahd

Subjects
MYOCARDITIS, VACCINE safety, MEDICAL sciences
Abstract

More than 10 billion doses of COVID-19 vaccines have been administered worldwide in the span of 18 months, providing an unprecedented opportunity to study and understand immunological responses and clinical reactions to vaccines. Myocarditis (with or without pericarditis) following vaccination with COVID-19 mRNA vaccines is the serious adverse event most closely monitored by national agencies and vaccine producers [[11]]. It is unknown whether they are triggered by the adjuvant (lipid nanoparticles for the mRNA vaccines), the vaccine antigen (the perfusion-stabilized spike protein translated by the human cells), the core components of the vaccine (the nucleoside-modified mRNA), or a combination thereof. COVID-19 mRNA vaccines are very effective at preventing hypoxemic COVID-19 pneumonia. [Extracted from the article]

Published
2022
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10. IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2

Author

Shen-Ying Zhang, Paul Bastard, Marc Lecuit, Jean-Laurent Casanova, Romain Lévy, and Fanny Lanternier

Subjects
medicine.medical_specialty, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Alpha interferon, Letter to Editor, Virology, law.invention, Medical microbiology, law, TLR3, medicine, Recombinant DNA, Immunology and Allergy, IRF3, business, Interferon alfa, Interferon type I, medicine.drug
Published
2021

11. X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.

Author

Abolhassani, Hassan, Vosughimotlagh, Ahmad, Asano, Takaki, Landegren, Nils, Boisson, Bertrand, Delavari, Samaneh, Bastard, Paul, Aranda-Guillén, Maribel, Wang, Yating, Zuo, Fanglei, Sardh, Fabian, Marcotte, Harold, Du, Likun, Zhang, Shen-Ying, Zhang, Qian, Rezaei, Nima, Kämpe, Olle, Casanova, Jean-Laurent, Hammarström, Lennart, and Pan-Hammarström, Qiang

Subjects
CORONAVIRUS diseases, TYPE I interferons, COVID-19, THERAPEUTICS, VIRAL antibodies, SYMPTOMS
Abstract

Background: Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is instrumental for disease prevention and treatment in individuals with a high risk. Objectives: We aimed to identify the genetic cause for critical COVID-19 pneumonia in a patient with a preexisting inborn error of immunity (IEI). Methods: Serum levels of specific antibodies against the virus and autoantibodies against type I interferons (IFNs) were measured. Whole exome sequencing was performed, and the impacts of candidate gene variants were investigated. We also evaluated 247 ataxia-telangiectasia (A-T) patients in the Iranian IEI registry. Results: We report a 7-year-old Iranian boy with a preexisting hyper IgM syndrome who developed critical COVID-19 pneumonia. IgM only specific COVID-19 immune response was detected but no autoantibodies against type I IFN were observed. A homozygous deleterious mutation in the ATM gene was identified, which together with his antibody deficiency, radiosensitivity, and neurological signs, established a diagnosis of A-T. Among the 247 A-T patients evaluated, 36 had SARS-CoV-2 infection, but all had mild symptoms or were asymptomatic except the index patient. A hemizygous deleterious mutation in the TLR7 gene was subsequently identified in the patient. Conclusions: We report a unique IEI patient with combined ATM and TLR7 deficiencies. The two genetic defects underlie A-T and critical COVID-19 in this patient, respectively. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis

Author

Partanen, Terhi, primary, Chen, Jie, additional, Lehtonen, Johanna, additional, Kuismin, Outi, additional, Rusanen, Harri, additional, Vapalahti, Olli, additional, Vaheri, Antti, additional, Anttila, Veli-Jukka, additional, Bode, Michaela, additional, Hautala, Nina, additional, Vuorinen, Tytti, additional, Glumoff, Virpi, additional, Kraatari, Minna, additional, Åström, Pirjo, additional, Saarela, Janna, additional, Kauma, Heikki, additional, Lorenzo, Lazaro, additional, Casanova, Jean-Laurent, additional, Zhang, Shen-Ying, additional, Seppänen, Mikko, additional, and Hautala, Timo, additional

Published
2020
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13. Correction to: IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2

Author

Marc Lecuit, Paul Bastard, Jean-Laurent Casanova, Romain Lévy, Shen-Ying Zhang, and Fanny Lanternier

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Medical microbiology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Immunology and Allergy, Medicine, Correction, business, Virology
Published
2021

14. Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency

Author

Edgar de Borges de Oliveira, María Teresa Martínez-Saavedra, M López-Rodríguez, Michael J. Ciancanelli, Inmaculada Casas, Carlos Rodríguez-Gallego, Jose M. Ferrer, Ithaisa Sologuren, Felipe Rodríguez de Castro, Cristina Bilbao, Roger Colobran, Miguel Andújar-Sánchez, Mónica Martínez-Gallo, José Pestano, Jean-Laurent Casanova, Estefanía Herrera-Ramos, Shen-Ying Zhang, Jordi Solé-Violán, Mercedes Álvarez Fernández, C. Perez, Carmen Oleaga-Quintas, Nieves Franco, E. Betancor, Jacinta Bustamante, and José Juan Ruiz-Hernández

Subjects
0301 basic medicine, Male, GATA2 Deficiency, Immunology, DNA Mutational Analysis, Viremia, Disease, medicine.disease_cause, Article, Immunophenotyping, immunological memory, Pathogenesis, 03 medical and health sciences, Immune system, Fatal Outcome, Influenza, Human, GATA2, Influenza A virus, medicine, Immunodeficiency, influenza A virus, Immunology and Allergy, Humans, Young adult, business.industry, H1N1, medicine.disease, Lymphocyte Subsets, 3. Good health, Pedigree, GATA2 Transcription Factor, 030104 developmental biology, Mutation, Cytokines, Female, business, Biomarkers
Abstract

The pathogenesis of life-threatening influenza A virus (IAV) disease remains elusive, as infection is benign in most individuals. We studied two relatives who died from influenza. We Sanger sequenced GATA2 and evaluated the mutation by gene transfer, measured serum cytokine levels, and analyzed circulating T- and B-cells. Both patients (father and son, P1 and P2) died in 2011 of H1N1pdm IAV infection at the ages of 54 and 31 years, respectively. They had not suffered from severe or moderately severe infections in the last 17 (P1) and 15 years (P2). A daughter of P1 had died at 20 years from infectious complications. Low B-cell, NK- cell, and monocyte numbers and myelodysplastic syndrome led to sequence GATA2. Patients were heterozygous for a novel, hypomorphic, R396L mutation leading to haplo-insufficiency. B- and T-cell rearrangement in peripheral blood from P1 during the influenza episode showed expansion of one major clone. No T-cell receptor excision circles were detected in P1 and P3 since they were 35 and 18 years, respectively. Both patients presented an exuberant, interferon (IFN)-γ-mediated hypercytokinemia during H1N1pdm infection. No data about patients with viremia was available. Two previously reported adult GATA2-deficient patients died from severe H1N1 IAV infection; GATA2 deficiency may predispose to life-threatening influenza in adulthood. However, a role of other genetic variants involved in immune responses cannot be ruled out. Patients with GATA2 deficiency can reach young adulthood without severe infections, including influenza, despite long-lasting complete B-cell and natural killer (NK) cell deficiency, as well as profoundly diminished T-cell thymic output.

Published
2017

15. Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency

Author

Sologuren, Ithaisa, primary, Martínez-Saavedra, María Teresa, additional, Solé-Violán, Jordi, additional, de Borges de Oliveira Jr, Edgar, additional, Betancor, Eva, additional, Casas, Inmaculada, additional, Oleaga-Quintas, Carmen, additional, Martínez-Gallo, Mónica, additional, Zhang, Shen-Ying, additional, Pestano, Jose, additional, Colobran, Roger, additional, Herrera-Ramos, Estefanía, additional, Pérez, Carmen, additional, López-Rodríguez, Marta, additional, Ruiz-Hernández, José Juan, additional, Franco, Nieves, additional, Ferrer, José María, additional, Bilbao, Cristina, additional, Andújar-Sánchez, Miguel, additional, Álvarez Fernández, Mercedes, additional, Ciancanelli, Michael J., additional, Rodríguez de Castro, Felipe, additional, Casanova, Jean-Laurent, additional, Bustamante, Jacinta, additional, and Rodríguez-Gallego, Carlos, additional

Published
2018
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16. EVER2 Deficiency is Associated with Mild T-cell Abnormalities

Author

Crequer, Amandine, primary, Picard, Capucine, additional, Pedergnana, Vincent, additional, Lim, Annick, additional, Zhang, Shen-Ying, additional, Abel, Laurent, additional, Majewski, Slawomir, additional, Casanova, Jean-Laurent, additional, Jablonska, Stefania, additional, Orth, Gerard, additional, and Jouanguy, Emmanuelle, additional

Published
2012
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