1. Foxp3+ Regulatory T Cells in Mouse Models of Type 1 Diabetes.
- Author
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Petzold, Cathleen, Riewaldt, Julia, Watts, Deepika, Sparwasser, Tim, Schallenberg, Sonja, and Kretschmer, Karsten
- Subjects
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TYPE 1 diabetes , *T cells , *LABORATORY mice , *DIABETES complications , *DIABETES , *HOMEOSTASIS , *AUTOIMMUNITY - Abstract
Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4+CD25+ regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3+ Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3+ Treg cells. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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