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Start Over Author "Radzio, Jessica" Journal journal of infectious diseases
2 results on '"Radzio, Jessica"'

1. Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques HarboringChlamydia trachomatisandTrichomonas vaginalis

Author

Radzio, Jessica, primary, Henning, Tara, additional, Jenkins, Leecresia, additional, Ellis, Shanon, additional, Farshy, Carol, additional, Phillips, Christi, additional, Holder, Angela, additional, Kuklenyik, Susan, additional, Dinh, Chuong, additional, Hanson, Debra, additional, McNicholl, Janet, additional, Heneine, Walid, additional, Papp, John, additional, Kersh, Ellen N., additional, and García-Lerma, J. Gerardo, additional

Published
2016
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2. Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques Harboring Chlamydia trachomatis and Trichomonas vaginalis.

Author

Radzio, Jessica, Henning, Tara, Jenkins, Leecresia, Ellis, Shanon, Farshy, Carol, Phillips, Christi, Holder, Angela, Kuklenyik, Susan, Dinh, Chuong, McNicholl, Janet, Heneine, Walid, Papp, John, Kersh, Ellen N., Gerardo García-Lerma, J., Hanson, Debra, and García-Lerma, J Gerardo

Subjects
*TENOFOVIR, *BISOPROLOL, *MEDICAL microbiology, *HUMAN microbiota, *MEDICAL bacteriology, *HIV prevention, *ANTI-HIV agents, *RNA virus infections, *ANIMAL experimentation, *BIOLOGICAL models, *CHLAMYDIA infections, *CHLAMYDIA trachomatis, *TRICHOMONAS vaginalis, *PREVENTIVE health services, *PRIMATES, *RESEARCH funding, *VAGINA, *MIXED infections, *DISEASE complications, *PREVENTION
Abstract

Genital inflammation associated with sexually transmitted infections increases susceptibility to human immunodeficiency virus (HIV), but it is unclear whether the increased risk can reduce the efficacy of pre-exposure prophylaxis (PrEP). We investigated whether coinfection of macaques with Chlamydia trachomatis and Trichomonas vaginalis decreases the prophylactic efficacy of oral emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF). Macaques were exposed to simian/human immunodeficiency virus (SHIV) vaginally each week for up to 16 weeks and received placebo or FTC/TDF pericoitally. All animals in the placebo group were infected with SHIV, while 4 of 6 PrEP recipients remained uninfected (P= .03). Oral FTC/TDF maintains efficacy in a macaque model of sexually transmitted coinfection, although the infection of 2 macaques signals a modest loss of PrEP activity. [ABSTRACT FROM AUTHOR]

Published
2016
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