1. In vivo investigation of cobalt ferrite-based magnetic fluid and magnetoliposomes using morphological tests
- Author
-
M.F. Carneiro, S.C. Reis, Antonio Claudio Tedesco, Z.G.M. Lacava, Selma A S Kuckelhaus, Emília Celma de Oliveira Lima, Ricardo Bentes Azevedo, Paulo C. Morais, and D. M. Oliveira
- Subjects
Ferrofluid ,Materials science ,Biocompatibility ,chemistry.chemical_element ,Condensed Matter Physics ,Biocompatible material ,Electronic, Optical and Magnetic Materials ,Nuclear magnetic resonance ,chemistry ,In vivo ,Cobalt ferrite ,Cluster size ,Magnetic nanoparticles ,Cobalt ,Biomedical engineering - Abstract
Morphological studies were carried out after endovenous injection of a magnetic fluid and magnetoliposome samples, all containing cobalt ferrite magnetic nanoparticles (MNPs). Twenty four hours after injection, the three investigated samples presented differences concerning blood clearance, phagocytosis susceptibility, and MNP cluster size and amount. Our data suggest that the samples investigated are biocompatible and could be used as material basis for biomedical applications. Further, differences observed in the in vivo tests support application of the samples for different biomedical purposes.
- Published
- 2004
- Full Text
- View/download PDF