1. The Relationship of the Post-reflux Swallow-induced Peristaltic Wave Index and Esophageal Baseline Impedance with Gastroesophageal Reflux Disease Symptoms
- Author
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Su Jin Hong, Seong Ran Jeon, Sang Joon Park, Tae Hee Lee, Joon Seong Lee, Hyun Gun Kim, Young Kyu Cho, and Jin Oh Kim
- Subjects
medicine.medical_specialty ,Disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Heartburn ,PSPW index ,Internal medicine ,Esophageal baseline impedance ,medicine ,otorhinolaryngologic diseases ,Baseline impedance ,Esophagus ,Peristalsis ,business.industry ,Reflux ,Dysphagia ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,Gastroesophageal reflux ,030220 oncology & carcinogenesis ,GERD ,030211 gastroenterology & hepatology ,Original Article ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Background/Aims The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with reflux symptoms is not known. We aim to evaluate the correlations of PSPW index and esophageal BI with gastroesophageal reflux disease (GERD) symptoms. Methods We performed a retrospective review of multichannel intraluminal impedance and pH (MII-pH) tracings in patients with suspected GERD. Reflux symptoms were also analyzed from checklists using ordinal scales. The PSPW index and esophageal BIs in 6 spots (z1-z6) were measured. Bivariate (Spearman) correlation was used to analyze the relationship between the PSPW index or esophageal BI, and the degree of GERD symptoms measured. Results The MII-pH records of 143 patients were analyzed. The PSPW index was significantly lower in patients who had heartburn and negatively correlated with the degree of heartburn (r = -0.186, P < 0.05). On the contrary, the PSPW index was not significantly correlated with the degree of dysphagia (r = -0.013, P = 0.874). Distal esophageal BI was not significantly correlated with heartburn, but negatively correlated with the degree of dysphagia (z3: r = -0.328, z4: r = -0.361, z5: r = -0.316, z6: r = -0.273; P < 0.05). Conclusions These findings suggest that delayed chemical clearance of the esophagus may induce heartburn, but that it is not related to dysphagia. However, a lack of esophageal mucosal integrity may be related to dysphagia.
- Published
- 2017