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An efficient pyridinium ylide assisted synthetic procedure for the preparation of fused 2,3-dihydrofuran derivatives is presented. [Super 1]H NMR spectroscopy and single-crystal analysis demonstrated the obtained 2,3-dihydrofurans to be trans isomers.

The domino reactions of 1,3-thiazolidinedione, malononitrile, and aromatic aldehydes in the presence of different organic amines are analyzed. Bulky diethylamine, diisopropylamine, and 1,4-diazabicyclo[2.2.2]octane has given spirocyclohexano-1,3-thiazole through a double Michael addition/spirocyclization reaction.

Four-component reaction of pyridine or 3-picoline, chloroacetonitrile, malononitrile, and aromatic aldehyde in refluxing acetonitrile is used to perform one-pot synthesis of polysubstituted pyrido[1,2-a]benzimidazole derivatives. The reaction mechanism involved the formation of polysubstituted benzenes with subsequent substitution and annulation reaction of pyridine.

Polysubstituted pyrido[1,2-α]benzimidazole derivatives are efficiently produced in moderate yields in a novel one-pot, four-component reaction from pyridine or 3-picoline, chloroacetonitrile, malononitrile, and aromatic aldehyde in refluxing acetonitrile. The mechanism of this novel reaction was believed involving the formation of polysubstituted benzenes with subsequent substitution and annulation reaction of pyridine. All pyrido[1,2-α]benzimidazoles, polysubstituted benzenes, polysubstituted indoles, and some key reaction intermediates are characterized by 1H and 13C NMR, MS, IR spectra, and elemental analysis as well as X-ray crystallography. [ABSTRACT FROM AUTHOR]