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Research has been conducted on the vinyldiazoacetates. The results of the dirhodium tetracarboxylate catalyzed decomposition of these compounds carried out in the presence of N-phenoxycarbonyl protected 1,2-dihydropyridines or 1-methyl-2-pyridones in producing 6-azabicyclo[3.2.2]nonane ring system are reported.

Research has been conducted on the bridging heteroatom beta. The hypothesis that the heteroatom attached beta to the carbonyl mediates the steric or electronic barrier to the transition state in protonating the enolate from the top or exo face has been investigated and is reported.

A study of the reactivity of 4,5-eta(super 2)-pyrrole complexes shows that these complexes undergo electrophilic addition reactions to form beta-substituted pyrroles. Reaction with alpha,beta-unsaturated carbonyl compounds results in the formation of 1,3-dipolar cycloaddition adducts that ring-open to form alpha-substituted pyrrole with osmium at 3,4 position. Combination of pyrrole complexes with alkyne Michael acceptors helps in capturing the iminium carbon of the 3H-pyrrolium species to form metalated cyclobutene derivatives.

Pyrroles which can give four activated carbons in a hetrerocyclic ring are an essential section of synthons for alkaloids. Studies were conducted to find how dearomatization methodology can be used in organic synthesis. Moderate Michael acceptors can be selectively added to the alpha-carbon or beta-carbon to form substituted pyrrolizinones, 1H pyrroles or 7-azanorbornenes through coordination. A mixture of products is produced by the reaction of uncomplexed pyrroles with Michael acceptors. Electron-deficient olefines and an eta squared pyrrole can provide two modes of addition depending on the place of metal coordination. The uncoordinated fragment of the 3,4-eta squared form is more reactive than the 4,5-eta squared form for certain electrophiles.

Surveys the reactivity of a series of pyrrole complexes of the form [Os(NH3)5(4,5-eta2-L)]2+(OTf)2 (L = pyrrole and alkylated pyrroles) with various electrophiles which include acids, alkyl triflates, anhydrides, aldehydes, ketones and Michael acceptors. Alkylation or acylation of the pyrrole ligand.

Reports on the use of Eta2-Pyrrole complexes combined with Michael acceptors to yield alkaloid derivatives. Generation of pyrrole complexes from reduction of Os(NH3)5(OTf)3; Reactions of uncomplexed pyrroles.