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Start Over Author "Zhigang Zeng" Journal journal of pesticide science
3 results on '"Zhigang Zeng"'

1. Synthesis and biological activity of arylsulfonamide derivatives containing 2-arylamino-4(3

Author

Zhigang, Zeng, Tao, Gao, Yan, Li, Xiang, Wang, Xuhong, Yang, and Minghu, Wu

Subjects
Note
Abstract

Twenty arylsulfonamide derivatives containing 2-arylamino-4(3H)-quinazolinone were synthesized and evaluated for their bioactivities. 4-Fluoro-N-(2-(4-oxo-2-(4-(trifluoromethoxy)phenyl)amino)quinazolin-3(4H)-yl)ethyl benzenesulfonamide, showed excellent activity both against Ralstonia solanacearum and Gibberella zeae with the inhibition rates of 100% (200 mg/L) and 95% (100 mg/L), and 69% (50 mg/L), respectively, exceeding that of the assigned commercial bactericide (thiodiazole-copper) and fungicide (hymexazol). The preliminary structure activity relationships (SAR) showed that both benzene rings of arylamino and arylsulfonamido moieties containing electron-withdrawing substitutes may be preferable for improving the bioactivity of target compounds.

Published
2018

2. Synthesis and biological activity of arylsulfonamide derivatives containing 2-arylamino-4(3H)-quinazolinone

Author

Yan Li, Tao Gao, Zhigang Zeng, Xuhong Yang, Minghu Wu, and Xiang Wang

Subjects
Ralstonia solanacearum, biology, 010405 organic chemistry, Health, Toxicology and Mutagenesis, Biological activity, biology.organism_classification, 01 natural sciences, Combinatorial chemistry, Medicinal chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Gibberella zeae, chemistry, Insect Science, Antibacterial activity, Benzene, Quinazolinone
Abstract

Twenty arylsulfonamide derivatives containing 2-arylamino-4(3H)-quinazolinone were synthesized and evaluated for their bioactivities. 4-Fluoro-N-(2-(4-oxo-2-(4-(trifluoromethoxy)phenyl)amino)quinazolin-3(4H)-yl)ethyl benzenesulfonamide, showed excellent activity both against Ralstonia solanacearum and Gibberella zeae with the inhibition rates of 100% (200 mg/L) and 95% (100 mg/L), and 69% (50 mg/L), respectively, exceeding that of the assigned commercial bactericide (thiodiazole-copper) and fungicide (hymexazol). The preliminary structure activity relationships (SAR) showed that both benzene rings of arylamino and arylsulfonamido moieties containing electron-withdrawing substitutes may be preferable for improving the bioactivity of target compounds.

Published
2016

3. Synthesis and biological activity of arylsulfonamide derivatives containing 2-arylamino- 4(3H)-quinazolinone.

Author

Zhigang ZENG, Tao GAO, Yan LI, Xiang WANG, Xuhong YANG, and Minghu WU

Subjects
*CHEMICAL synthesis, *CHEMICAL derivatives, *RALSTONIA solanacearum, *STRUCTURE-activity relationship in pharmacology, *GIBBERELLA zeae
Abstract

Twenty arylsulfonamide derivatives containing 2-arylamino-4(3H)-quinazolinone were synthesized and evaluated for their bioactivities. 4-Fluoro- N-(2-(4-oxo-2-(4-(trifluoromethoxy)phenyl)amino)quinazolin-3(4H)-yl)ethyl benzenesulfonamide, showed excellent activity both against Ralstonia solanacearum and Gibberella zeae with the inhibition rates of 100% (200 mg/L) and 95% (100 mg/L), and 69% (50 mg/L), respectively, exceeding that of the assigned commercial bactericide (thiodiazole-copper) and fungicide (hymexazol). The preliminary structure activity relationships (SAR) showed that both benzene rings of arylamino and arylsulfonamido moieties containing electron-withdrawing substitutes may be preferable for improving the bioactivity of target compounds. [ABSTRACT FROM AUTHOR]

Published
2016
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